NEDD9

From Wikipedia, the free encyclopedia

Neural precursor cell expressed, developmentally down-regulated 9

Identifiers

NEDD9; CAS-L; CASL; HEF1; dJ49G10.2; dJ761I2.1

External IDs

OMIM: 602265 MGI: 97302 HomoloGene: 4669

Gene ontology
Molecular Function:	• protein binding
Cellular Component:	• nucleus • cytoplasm • spindle • cytoskeleton
Biological Process:	• regulation of progression through cell cycle • regulation of cell growth • cytoskeleton organization and biogenesis • cell cycle • mitosis • cell adhesion • signal transduction • integrin-mediated signaling pathway • actin filament bundle formation • cell division

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_006403 (mRNA)
NP_006394 (protein)

NM_017464 (mRNA)
NP_059492 (protein)

Location

Chr 6: 11.29 - 11.49 Mb

Chr 13: 41.32 - 41.35 Mb

Pubmed search

[1]

[2]

Neural precursor cell expressed, developmentally down-regulated 9, also known as NEDD9, is a human gene.^[1]

[edit] References

^ Entrez Gene: NEDD9 neural precursor cell expressed, developmentally down-regulated 9.

[edit] Further reading

Iwata S, Ohashi Y, Kamiguchi K, Morimoto C (2000). "Beta 1-integrin-mediated cell signaling in T lymphocytes.". J. Dermatol. Sci. 23 (2): 75-86. PMID 10808124.
O'Neill GM, Seo S, Serebriiskii IG, et al. (2007). "A new central scaffold for metastasis: parsing HEF1/Cas-L/NEDD9.". Cancer Res. 67 (19): 8975-9. doi:10.1158/0008-5472.CAN-07-1328. PMID 17908996.
Law SF, Estojak J, Wang B, et al. (1996). "Human enhancer of filamentation 1, a novel p130cas-like docking protein, associates with focal adhesion kinase and induces pseudohyphal growth in Saccharomyces cerevisiae.". Mol. Cell. Biol. 16 (7): 3327-37. PMID 8668148.
Minegishi M, Tachibana K, Sato T, et al. (1996). "Structure and function of Cas-L, a 105-kD Crk-associated substrate-related protein that is involved in beta 1 integrin-mediated signaling in lymphocytes.". J. Exp. Med. 184 (4): 1365-75. PMID 8879209.
Manié SN, Beck AR, Astier A, et al. (1997). "Involvement of p130(Cas) and p105(HEF1), a novel Cas-like docking protein, in a cytoskeleton-dependent signaling pathway initiated by ligation of integrin or antigen receptor on human B cells.". J. Biol. Chem. 272 (7): 4230-6. PMID 9020138.
Tachibana K, Urano T, Fujita H, et al. (1997). "Tyrosine phosphorylation of Crk-associated substrates by focal adhesion kinase. A putative mechanism for the integrin-mediated tyrosine phosphorylation of Crk-associated substrates.". J. Biol. Chem. 272 (46): 29083-90. PMID 9360983.
Hunter AJ, Shimizu Y (1997). "Alpha 4 beta 1 integrin-mediated tyrosine phosphorylation in human T cells: characterization of Crk- and Fyn-associated substrates (pp105, pp115, and human enhancer of filamentation-1) and integrin-dependent activation of p59fyn1.". J. Immunol. 159 (10): 4806-14. PMID 9366405.
de Jong R, van Wijk A, Haataja L, et al. (1998). "BCR/ABL-induced leukemogenesis causes phosphorylation of Hef1 and its association with Crkl.". J. Biol. Chem. 272 (51): 32649-55. PMID 9405482.
Ohashi Y, Tachibana K, Kamiguchi K, et al. (1998). "T cell receptor-mediated tyrosine phosphorylation of Cas-L, a 105-kDa Crk-associated substrate-related protein, and its association of Crk and C3G.". J. Biol. Chem. 273 (11): 6446-51. PMID 9497377.
Astier A, Manié SN, Law SF, et al. (1998). "Association of the Cas-like molecule HEF1 with CrkL following integrin and antigen receptor signaling in human B-cells: potential relevance to neoplastic lymphohematopoietic cells.". Leuk. Lymphoma 28 (1-2): 65-72. PMID 9498705.
Law SF, Zhang YZ, Klein-Szanto AJ, Golemis EA (1998). "Cell cycle-regulated processing of HEF1 to multiple protein forms differentially targeted to multiple subcellular compartments.". Mol. Cell. Biol. 18 (6): 3540-51. PMID 9584194.
Côté JF, Charest A, Wagner J, Tremblay ML (1998). "Combination of gene targeting and substrate trapping to identify substrates of protein tyrosine phosphatases using PTP-PEST as a model.". Biochemistry 37 (38): 13128-37. doi:10.1021/bi981259l. PMID 9748319.
Kyono WT, de Jong R, Park RK, et al. (1998). "Differential interaction of Crkl with Cbl or C3G, Hef-1, and gamma subunit immunoreceptor tyrosine-based activation motif in signaling of myeloid high affinity Fc receptor for IgG (Fc gamma RI).". J. Immunol. 161 (10): 5555-63. PMID 9820532.
Zhang Z, Hernandez-Lagunas L, Horne WC, Baron R (1999). "Cytoskeleton-dependent tyrosine phosphorylation of the p130(Cas) family member HEF1 downstream of the G protein-coupled calcitonin receptor. Calcitonin induces the association of HEF1, paxillin, and focal adhesion kinase.". J. Biol. Chem. 274 (35): 25093-8. PMID 10455189.
Ohashi Y, Iwata S, Kamiguchi K, Morimoto C (1999). "Tyrosine phosphorylation of Crk-associated substrate lymphocyte-type is a critical element in TCR- and beta 1 integrin-induced T lymphocyte migration.". J. Immunol. 163 (7): 3727-34. PMID 10490968.
Law SF, Zhang YZ, Fashena SJ, et al. (1999). "Dimerization of the docking/adaptor protein HEF1 via a carboxy-terminal helix-loop-helix domain.". Exp. Cell Res. 252 (1): 224-35. doi:10.1006/excr.1999.4609. PMID 10502414.
Scanlan MJ, Gordan JD, Williamson B, et al. (1999). "Antigens recognized by autologous antibody in patients with renal-cell carcinoma.". Int. J. Cancer 83 (4): 456-64. PMID 10508479.
Sakakibara A, Hattori S (2000). "Chat, a Cas/HEF1-associated adaptor protein that integrates multiple signaling pathways.". J. Biol. Chem. 275 (9): 6404-10. PMID 10692442.
Law SF, O'Neill GM, Fashena SJ, et al. (2000). "The docking protein HEF1 is an apoptotic mediator at focal adhesion sites.". Mol. Cell. Biol. 20 (14): 5184-95. PMID 10866674.