NEDD4

From Wikipedia, the free encyclopedia


Neural precursor cell expressed, developmentally down-regulated 4
Identifiers
Symbol(s) NEDD4; KIAA0093
External IDs OMIM: 602278 HomoloGene: 89305
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 4734 n/a
Ensembl ENSG00000069869 n/a
Uniprot P46934 n/a
Refseq NM_006154 (mRNA)
NP_006145 (protein)		 n/a (mRNA)
n/a (protein)
Location Chr 15: 53.91 - 54.07 Mb n/a
Pubmed search [1] n/a

Neural precursor cell expressed, developmentally down-regulated 4, also known as NEDD4, is a human gene.


  • Nagase T, Miyajima N, Tanaka A, et al. (1995). "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1.". DNA Res. 2 (1): 37–43. PMID 7788527. 
  • Imhof MO, McDonnell DP (1996). "Yeast RSP5 and its human homolog hRPF1 potentiate hormone-dependent activation of transcription by human progesterone and glucocorticoid receptors.". Mol. Cell. Biol. 16 (6): 2594–605. PMID 8649367. 
  • Kumar S, Harvey KF, Kinoshita M, et al. (1997). "cDNA cloning, expression analysis, and mapping of the mouse Nedd4 gene.". Genomics 40 (3): 435–43. doi:10.1006/geno.1996.4582. PMID 9073511. 
  • Hatakeyama S, Jensen JP, Weissman AM (1997). "Subcellular localization and ubiquitin-conjugating enzyme (E2) interactions of mammalian HECT family ubiquitin protein ligases.". J. Biol. Chem. 272 (24): 15085–92. PMID 9182527. 
  • Gavva NR, Gavva R, Ermekova K, et al. (1997). "Interaction of WW domains with hematopoietic transcription factor p45/NF-E2 and RNA polymerase II.". J. Biol. Chem. 272 (39): 24105–8. PMID 9305852. 
  • Staub O, Gautschi I, Ishikawa T, et al. (1998). "Regulation of stability and function of the epithelial Na+ channel (ENaC) by ubiquitination.". EMBO J. 16 (21): 6325–36. doi:10.1093/emboj/16.21.6325. PMID 9351815. 
  • Plant PJ, Yeger H, Staub O, et al. (1998). "The C2 domain of the ubiquitin protein ligase Nedd4 mediates Ca2+-dependent plasma membrane localization.". J. Biol. Chem. 272 (51): 32329–36. PMID 9405440. 
  • Ott DE, Coren LV, Copeland TD, et al. (1998). "Ubiquitin is covalently attached to the p6Gag proteins of human immunodeficiency virus type 1 and simian immunodeficiency virus and to the p12Gag protein of Moloney murine leukemia virus.". J. Virol. 72 (4): 2962–8. PMID 9525617. 
  • Harvey KF, Harvey NL, Michael JM, et al. (1998). "Caspase-mediated cleavage of the ubiquitin-protein ligase Nedd4 during apoptosis.". J. Biol. Chem. 273 (22): 13524–30. PMID 9593687. 
  • Anan T, Nagata Y, Koga H, et al. (1999). "Human ubiquitin-protein ligase Nedd4: expression, subcellular localization and selective interaction with ubiquitin-conjugating enzymes.". Genes Cells 3 (11): 751–63. PMID 9990509. 
  • Lu PJ, Zhou XZ, Shen M, Lu KP (1999). "Function of WW domains as phosphoserine- or phosphothreonine-binding modules.". Science 283 (5406): 1325–8. PMID 10037602. 
  • Harvey KF, Dinudom A, Komwatana P, et al. (1999). "All three WW domains of murine Nedd4 are involved in the regulation of epithelial sodium channels by intracellular Na+.". J. Biol. Chem. 274 (18): 12525–30. PMID 10212229. 
  • Morrione A, Plant P, Valentinis B, et al. (1999). "mGrb10 interacts with Nedd4.". J. Biol. Chem. 274 (34): 24094–9. PMID 10446181. 
  • Farr TJ, Coddington-Lawson SJ, Snyder PM, McDonald FJ (2000). "Human Nedd4 interacts with the human epithelial Na+ channel: WW3 but not WW1 binds to Na+-channel subunits.". Biochem. J. 345 Pt 3: 503–9. PMID 10642508. 
  • Plant PJ, Lafont F, Lecat S, et al. (2000). "Apical membrane targeting of Nedd4 is mediated by an association of its C2 domain with annexin XIIIb.". J. Cell Biol. 149 (7): 1473–84. PMID 10871286. 
  • Jolliffe CN, Harvey KF, Haines BP, et al. (2001). "Identification of multiple proteins expressed in murine embryos as binding partners for the WW domains of the ubiquitin-protein ligase Nedd4.". Biochem. J. 351 Pt 3: 557–65. PMID 11042109. 
  • Winberg G, Matskova L, Chen F, et al. (2000). "Latent membrane protein 2A of Epstein-Barr virus binds WW domain E3 protein-ubiquitin ligases that ubiquitinate B-cell tyrosine kinases.". Mol. Cell. Biol. 20 (22): 8526–35. PMID 11046148. 
  • Schubert U, Ott DE, Chertova EN, et al. (2001). "Proteasome inhibition interferes with gag polyprotein processing, release, and maturation of HIV-1 and HIV-2.". Proc. Natl. Acad. Sci. U.S.A. 97 (24): 13057–62. doi:10.1073/pnas.97.24.13057. PMID 11087859. 
  • Strack B, Calistri A, Accola MA, et al. (2001). "A role for ubiquitin ligase recruitment in retrovirus release.". Proc. Natl. Acad. Sci. U.S.A. 97 (24): 13063–8. doi:10.1073/pnas.97.24.13063. PMID 11087860. 
  • Ott DE, Coren LV, Chertova EN, et al. (2001). "Ubiquitination of HIV-1 and MuLV Gag.". Virology 278 (1): 111–21. doi:10.1006/viro.2000.0648. PMID 11112487. 
 This article on a gene on chromosome 15 is a stub. You can help Wikipedia by expanding it.