NEDD4L

From Wikipedia, the free encyclopedia

Neural precursor cell expressed, developmentally down-regulated 4-like

PDB rendering based on 1wr3.

Available structures: 1wr3, 1wr4, 1wr7, 2nsq, 2oni

Identifiers

Symbol(s)

NEDD4L; FLJ33870; KIAA0439; RSP5; hNedd4-2

External IDs

OMIM: 606384 MGI: 1933754 HomoloGene: 86986

Gene ontology
Molecular Function:	• ubiquitin-protein ligase activity • protein binding • ligase activity • sodium channel regulator activity
Cellular Component:	• intracellular
Biological Process:	• sodium ion transport • cellular sodium ion homeostasis • excretion • response to metal ion • protein ubiquitination • water homeostasis • regulation of protein catabolic process • positive regulation of endocytosis

Orthologs

Human

Mouse

Refseq

NM_015277 (mRNA)
NP_056092 (protein)

NM_031881 (mRNA)
NP_114087 (protein)

Location

Chr 18: 53.86 - 54.22 Mb

Chr 18: 65.05 - 65.34 Mb

Pubmed search

[1]

[2]

Neural precursor cell expressed, developmentally down-regulated 4-like, also known as NEDD4L, is a human gene.^[1]

[edit] References

^ Entrez Gene: NEDD4L Neural precursor cell expressed, developmentally down-regulated 4-like.

[edit] Further reading

Cook DI, Dinudom A, Komwatana P, et al. (2003). "Patch-clamp studies on epithelial sodium channels in salivary duct cells.". Cell Biochem. Biophys. 36 (2-3): 105–13. PMID 12139396.
Nuber U, Schwarz S, Kaiser P, et al. (1996). "Cloning of human ubiquitin-conjugating enzymes UbcH6 and UbcH7 (E2-F1) and characterization of their interaction with E6-AP and RSP5.". J. Biol. Chem. 271 (5): 2795–800. PMID 8576257.
Ishikawa K, Nagase T, Nakajima D, et al. (1998). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 4 (5): 307–13. PMID 9455477.
Erdeniz N, Rothstein R (2000). "Rsp5, a ubiquitin-protein ligase, is involved in degradation of the single-stranded-DNA binding protein rfa1 in Saccharomyces cerevisiae.". Mol. Cell. Biol. 20 (1): 224–32. PMID 10594025.
Winberg G, Matskova L, Chen F, et al. (2000). "Latent membrane protein 2A of Epstein-Barr virus binds WW domain E3 protein-ubiquitin ligases that ubiquitinate B-cell tyrosine kinases.". Mol. Cell. Biol. 20 (22): 8526–35. PMID 11046148.
Harvey KF, Dinudom A, Cook DI, Kumar S (2001). "The Nedd4-like protein KIAA0439 is a potential regulator of the epithelial sodium channel.". J. Biol. Chem. 276 (11): 8597–601. doi:10.1074/jbc.C000906200. PMID 11244092.
Kikonyogo A, Bouamr F, Vana ML, et al. (2001). "Proteins related to the Nedd4 family of ubiquitin protein ligases interact with the L domain of Rous sarcoma virus and are required for gag budding from cells.". Proc. Natl. Acad. Sci. U.S.A. 98 (20): 11199–204. doi:10.1073/pnas.201268998. PMID 11562473.
Snyder PM, Olson DR, Thomas BC (2002). "Serum and glucocorticoid-regulated kinase modulates Nedd4-2-mediated inhibition of the epithelial Na+ channel.". J. Biol. Chem. 277 (1): 5–8. doi:10.1074/jbc.C100623200. PMID 11696533.
Debonneville C, Flores SY, Kamynina E, et al. (2002). "Phosphorylation of Nedd4-2 by Sgk1 regulates epithelial Na(+) channel cell surface expression.". EMBO J. 20 (24): 7052–9. doi:10.1093/emboj/20.24.7052. PMID 11742982.
Harvey KF, Shearwin-Whyatt LM, Fotia A, et al. (2002). "N4WBP5, a potential target for ubiquitination by the Nedd4 family of proteins, is a novel Golgi-associated protein.". J. Biol. Chem. 277 (11): 9307–17. doi:10.1074/jbc.M110443200. PMID 11748237.
Chen H, Ross CA, Wang N, et al. (2002). "NEDD4L on human chromosome 18q21 has multiple forms of transcripts and is a homologue of the mouse Nedd4-2 gene.". Eur. J. Hum. Genet. 9 (12): 922–30. doi:10.1038/sj.ejhg.5200747. PMID 11840194.
Konstas AA, Shearwin-Whyatt LM, Fotia AB, et al. (2002). "Regulation of the epithelial sodium channel by N4WBP5A, a novel Nedd4/Nedd4-2-interacting protein.". J. Biol. Chem. 277 (33): 29406–16. doi:10.1074/jbc.M203018200. PMID 12050153.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Dunn DM, Ishigami T, Pankow J, et al. (2003). "Common variant of human NEDD4L activates a cryptic splice site to form a frameshifted transcript.". J. Hum. Genet. 47 (12): 665–76. doi:10.1007/s100380200102. PMID 12522688.
Asher C, Sinha I, Garty H (2003). "Characterization of the interactions between Nedd4-2, ENaC, and sgk-1 using surface plasmon resonance.". Biochim. Biophys. Acta 1612 (1): 59–64. PMID 12729930.
Itani OA, Campbell JR, Herrero J, et al. (2003). "Alternate promoters and variable splicing lead to hNedd4-2 isoforms with a C2 domain and varying number of WW domains.". Am. J. Physiol. Renal Physiol. 285 (5): F916–29. doi:10.1152/ajprenal.00203.2003. PMID 12876068.
Boehmer C, Henke G, Schniepp R, et al. (2003). "Regulation of the glutamate transporter EAAT1 by the ubiquitin ligase Nedd4-2 and the serum and glucocorticoid-inducible kinase isoforms SGK1/3 and protein kinase B.". J. Neurochem. 86 (5): 1181–8. PMID 12911626.
Malbert-Colas L, Nicolas G, Galand C, et al. (2004). "Identification of new partners of the epithelial sodium channel alpha subunit.". C. R. Biol. 326 (7): 615–24. PMID 14556380.
Qi H, Grenier J, Fournier A, Labrie C (2004). "Androgens differentially regulate the expression of NEDD4L transcripts in LNCaP human prostate cancer cells.". Mol. Cell. Endocrinol. 210 (1-2): 51–62. PMID 14615060.