Nebulette

Nebulette is an isoform of the protein nebulin. While nebulin (600-900 kDa) is expressed preferentially in skeletal muscle, nebulette (107 kDa) is expressed in cardiac muscle. Nebulette was identified in 1995 by Moncman and Wang using primary cultures of chicken embryonic cardiomyocytes by immunoprecipitations with certain anti-nebulin monoclonal antibodies.^[1] Normal expression of nebulette is essential for the assembly and contractile function of myofibrils.^[2]

[edit] References

^ Moncman & Wang (1995). "Nebulette: a 107 kD nebulin-like protein in cardiac muscle". Cell Motil Cytoskeleton 32 (3): 205–25. doi:10.1002/cm.970320305. PMID 8581976.
^ Moncman & Wang (2002). "Targeted disruption of nebulette protein expression alters cardiac myofibril assembly and function". Exp Cell Res 273 (2): 204–18. doi:10.1006/excr.2001.5423. PMID 11822876.

This article on a gene on chromosome 10 is a stub. You can help Wikipedia by expanding it.

This cell biology article is a stub. You can help Wikipedia by expanding it.

v • d • e Histology: muscle tissue

skeletal muscle/general	epimysium, fascicle, perimysium, endomysium, muscle fiber (intrafusal, extrafusal), myofibril sarcomere (a, i, and h bands; z and m lines), myofilaments (thin filament/actin, thick filament/myosin, elastic filament/titin, nebulin), tropomyosin, troponin (T, C, I) costamere (dystrophin, α,β-dystrobrevin, syncoilin, synemin/desmuslin, dysbindin, sarcoglycan, dystroglycan, sarcospan), desmin neuromuscular junction, motor unit, muscle spindle, excitation-contraction coupling, sliding filament mechanism myoblast, satellite cell, sarcoplasm, sarcolemma, sarcoplasmic reticulum, T-tubule

cardiac muscle	myocardium, intercalated disc, nebulette

smooth muscle	calmodulin, vascular smooth muscle