NDUFV3

From Wikipedia, the free encyclopedia

NADH dehydrogenase (ubiquinone) flavoprotein 3, 10kDa

Identifiers

External IDs

OMIM: 602184 MGI: 1925580 HomoloGene: 10885

Gene ontology
Molecular Function:	• NADH dehydrogenase activity • NADH dehydrogenase (ubiquinone) activity • oxidoreductase activity
Cellular Component:	• mitochondrion
Biological Process:	• mitochondrial electron transport, NADH to ubiquinone

Orthologs

Human

Mouse

Refseq

NM_001001503 (mRNA)
NP_001001503 (protein)

NM_030087 (mRNA)
NP_084363 (protein)

Location

Chr 21: 43.19 - 43.2 Mb

Chr 17: 31.25 - 31.26 Mb

Pubmed search

[1]

[2]

NADH dehydrogenase (ubiquinone) flavoprotein 3, 10kDa, also known as NDUFV3, is a human gene.^[1]

The protein encoded by this gene is one of at least forty-one subunits that make up the NADH-ubiquinone oxidoreductase complex. This complex is part of the mitochondrial respiratory chain and serves to catalyze the rotenone-sensitive oxidation of NADH and the reduction of ubiquinone. The encoded protein is one of three proteins found in the flavoprotein fraction of the complex. The specific function of the encoded protein is unknown. Two transcript variants encoding different isoforms have been found for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: NDUFV3 NADH dehydrogenase (ubiquinone) flavoprotein 3, 10kDa.

[edit] Further reading

Sled VD, Vinogradov AD (1993). "Kinetics of the mitochondrial NADH-ubiquinone oxidoreductase interaction with hexammineruthenium(III).". Biochim. Biophys. Acta 1141 (2-3): 262-8. PMID 8443212.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791-806. PMID 8889548.
de Coo RF, Buddiger P, Smeets HJ, van Oost BA (1998). "Molecular cloning and characterization of the human mitochondrial NADH:oxidoreductase 10-kDa gene (NDUFV3).". Genomics 45 (2): 434-7. doi:10.1006/geno.1997.4930. PMID 9344673.
Loeffen JL, Triepels RH, van den Heuvel LP, et al. (1999). "cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed.". Biochem. Biophys. Res. Commun. 253 (2): 415-22. doi:10.1006/bbrc.1998.9786. PMID 9878551.
Scanlan MJ, Gordan JD, Williamson B, et al. (1999). "Antigens recognized by autologous antibody in patients with renal-cell carcinoma.". Int. J. Cancer 83 (4): 456-64. PMID 10508479.
Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21.". Nature 405 (6784): 311-9. doi:10.1038/35012518. PMID 10830953.
Berry A, Scott HS, Kudoh J, et al. (2001). "Refined localization of autosomal recessive nonsyndromic deafness DFNB10 locus using 34 novel microsatellite markers, genomic structure, and exclusion of six known genes in the region.". Genomics 68 (1): 22-9. doi:10.1006/geno.2000.6253. PMID 10950923.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Zakharova NV, Zharova TV (2003). "Kinetic mechanism of mitochondrial NADH:ubiquinone oxidoreductase interaction with nucleotide substrates of the transhydrogenase reaction.". Biochemistry Mosc. 67 (12): 1395-404. PMID 12600270.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Kervinen M, Hinttala R, Helander HM, et al. (2006). "The MELAS mutations 3946 and 3949 perturb the critical structure in a conserved loop of the ND1 subunit of mitochondrial complex I.". Hum. Mol. Genet. 15 (17): 2543-52. doi:10.1093/hmg/ddl176. PMID 16849371.