NDUFS8

From Wikipedia, the free encyclopedia

NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase)

Identifiers

External IDs

OMIM: 602141 MGI: 2385079 HomoloGene: 1867

Gene ontology
Molecular Function:	• NADH dehydrogenase activity • iron ion binding • NADH dehydrogenase (ubiquinone) activity • metal ion binding • 4 iron, 4 sulfur cluster binding
Cellular Component:	• membrane fraction • mitochondrion
Biological Process:	• mitochondrial electron transport, NADH to ubiquinone

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002496 (mRNA)
NP_002487 (protein)

NM_144870 (mRNA)
NP_659119 (protein)

Location

Chr 11: 67.55 - 67.56 Mb

Chr 19: 3.91 - 3.91 Mb

Pubmed search

[1]

[2]

NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase), also known as NDUFS8, is a human gene.^[1]

[edit] References

^ Entrez Gene: NDUFS8 NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase).

[edit] Further reading

Procaccio V, Wallace DC (2004). "Late-onset Leigh syndrome in a patient with mitochondrial complex I NDUFS8 mutations.". Neurology 62 (10): 1899-901. PMID 15159508.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.
Procaccio V, Depetris D, Soularue P, et al. (1997). "cDNA sequence and chromosomal localization of the NDUFS8 human gene coding for the 23 kDa subunit of the mitochondrial complex I.". Biochim. Biophys. Acta 1351 (1-2): 37-41. PMID 9116042.
Dunbar DR, Shibasaki Y, Dobbie L, et al. (1997). "In situ hybridisation mapping of genomic clones for five human respiratory chain complex I genes.". Cytogenet. Cell Genet. 78 (1): 21-4. PMID 9345899.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
de Sury R, Martinez P, Procaccio V, et al. (1998). "Genomic structure of the human NDUFS8 gene coding for the iron-sulfur TYKY subunit of the mitochondrial NADH:ubiquinone oxidoreductase.". Gene 215 (1): 1-10. PMID 9666055.
Loeffen J, Smeitink J, Triepels R, et al. (1999). "The first nuclear-encoded complex I mutation in a patient with Leigh syndrome.". Am. J. Hum. Genet. 63 (6): 1598-608. PMID 9837812.
Loeffen JL, Triepels RH, van den Heuvel LP, et al. (1999). "cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed.". Biochem. Biophys. Res. Commun. 253 (2): 415-22. doi:10.1006/bbrc.1998.9786. PMID 9878551.
Triepels RH, Hanson BJ, van den Heuvel LP, et al. (2001). "Human complex I defects can be resolved by monoclonal antibody analysis into distinct subunit assembly patterns.". J. Biol. Chem. 276 (12): 8892-7. doi:10.1074/jbc.M009903200. PMID 11112787.
Lescuyer P, Martinez P, Lunardi J (2002). "YY1 and Sp1 activate transcription of the human NDUFS8 gene encoding the mitochondrial complex I TYKY subunit.". Biochim. Biophys. Acta 1574 (2): 164-74. PMID 11955626.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Murray J, Taylor SW, Zhang B, et al. (2003). "Oxidative damage to mitochondrial complex I due to peroxynitrite: identification of reactive tyrosines by mass spectrometry.". J. Biol. Chem. 278 (39): 37223-30. doi:10.1074/jbc.M305694200. PMID 12857734.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Ugalde C, Janssen RJ, van den Heuvel LP, et al. (2004). "Differences in assembly or stability of complex I and other mitochondrial OXPHOS complexes in inherited complex I deficiency.". Hum. Mol. Genet. 13 (6): 659-67. doi:10.1093/hmg/ddh071. PMID 14749350.
Bourges I, Ramus C, Mousson de Camaret B, et al. (2005). "Structural organization of mitochondrial human complex I: role of the ND4 and ND5 mitochondria-encoded subunits and interaction with prohibitin.". Biochem. J. 383 (Pt. 3): 491-9. doi:10.1042/BJ20040256. PMID 15250827.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.