NDUFB2

From Wikipedia, the free encyclopedia

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa

Identifiers

NDUFB2; AGGG; CI-AGGG; MGC70788

External IDs

OMIM: 603838 MGI: 1915448 HomoloGene: 3341

Gene ontology
Molecular Function:	• NADH dehydrogenase activity • NADH dehydrogenase (ubiquinone) activity • oxidoreductase activity
Cellular Component:	• membrane fraction • mitochondrion
Biological Process:	• mitochondrial electron transport, NADH to ubiquinone

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004546 (mRNA)
NP_004537 (protein)

NM_026612 (mRNA)
NP_080888 (protein)

Location

Chr 7: 140.04 - 140.07 Mb

Chr 6: 39.52 - 39.53 Mb

Pubmed search

[1]

[2]

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa, also known as NDUFB2, is a human gene.^[1]

The protein encoded by this gene is a subunit of the multisubunit NADH:ubiquinone oxidoreductase (complex I). Mammalian complex I is composed of 45 different subunits. This protein has NADH dehydrogenase activity and oxidoreductase activity. It plays a important role in transfering electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Hydropathy analysis revealed that this subunit and 4 other subunits have an overall hydrophilic pattern, even though they are found within the hydrophobic protein (HP) fraction of complex I.^[1]

[edit] References

^ ^a ^b Entrez Gene: NDUFB2 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa.

[edit] Further reading

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Yeh CH, Pang JH, Wu YC, et al. (2004). "Differential-display polymerase chain reaction identifies nicotinamide adenine dinucleotide-ubiquinone oxidoreductase as an ischemia/reperfusion-regulated gene in cardiomyocytes.". Chest 125 (1): 228-35. PMID 14718445.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology.". Science 300 (5620): 767-72. doi:10.1126/science.1083423. PMID 12690205.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.". Genome Res. 10 (10): 1546-60. PMID 11042152.
Loeffen JL, Triepels RH, van den Heuvel LP, et al. (1999). "cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed.". Biochem. Biophys. Res. Commun. 253 (2): 415-22. doi:10.1006/bbrc.1998.9786. PMID 9878551.
"Toward a complete human genome sequence." (1999). Genome Res. 8 (11): 1097-108. PMID 9847074.
Emahazion T, Beskow A, Gyllensten U, Brookes AJ (1998). "Intron based radiation hybrid mapping of 15 complex I genes of the human electron transport chain.". Cytogenet. Cell Genet. 82 (1-2): 115-9. PMID 9763677.