NDUFA5

From Wikipedia, the free encyclopedia

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5, 13kDa

Identifiers

NDUFA5; B13; CI-13KD-B; DKFZp781K1356; FLJ12147; NUFM; UQOR13

External IDs

OMIM: 601677 MGI: 1915452 HomoloGene: 3664

Gene ontology
Molecular Function:	• NADH dehydrogenase activity • NADH dehydrogenase (ubiquinone) activity • oxidoreductase activity, acting on NADH or NADPH
Cellular Component:	• mitochondrion • mitochondrial inner membrane
Biological Process:	• electron transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005000 (mRNA)
NP_004991 (protein)

NM_026614 (mRNA)
NP_080890 (protein)

Location

Chr 7: 122.96 - 122.99 Mb

Chr 6: 24.47 - 24.48 Mb

Pubmed search

[1]

[2]

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5, 13kDa, also known as NDUFA5, is a human gene.^[1]

The human NDUFA5 gene codes for the B13 subunit of complex I of the respiratory chain, which transfers electrons from NADH to ubiquinone. The high degree of conservation of NDUFA5 extending to plants and fungi indicates its functional significance in the enzyme complex. The protein localizes to the inner mitochondrial membrane as part of the 7 component-containing, water soluble "iron-sulfur protein" (IP) fraction of complex I, although its specific role is unknown. It is assumed to undergo post-translational removal of the initiator methionine and N-acetylation of the next amino acid. The predicted secondary structure is primarily alpha helix, but the carboxy-terminal half of the protein has high potential to adopt a coiled-coil form. The amino-terminal part contains a putative beta sheet rich in hydrophobic amino acids that may serve as mitochondrial import signal. Related pseudogenes have also been identified on four other chromosomes.^[1]

[edit] References

^ ^a ^b Entrez Gene: NDUFA5 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5, 13kDa.

[edit] Further reading

Smeitink J, van den Heuvel L (1999). "Human mitochondrial complex I in health and disease.". Am. J. Hum. Genet. 64 (6): 1505-10. PMID 10330338.
Russell MW, du Manoir S, Collins FS, Brody LC (1997). "Cloning of the human NADH: ubiquinone oxidoreductase subunit B13: localization to chromosome 7q32 and identification of a pseudogene on 11p15.". Mamm. Genome 8 (1): 60-1. PMID 9021153.
Pata I, Tensing K, Metspalu A (1997). "A human cDNA encoding the homologue of NADH: ubiquinone oxidoreductase subunit B13.". Biochim. Biophys. Acta 1350 (2): 115-8. PMID 9048877.
Emahazion T, Beskow A, Gyllensten U, Brookes AJ (1998). "Intron based radiation hybrid mapping of 15 complex I genes of the human electron transport chain.". Cytogenet. Cell Genet. 82 (1-2): 115-9. PMID 9763677.
"Toward a complete human genome sequence." (1999). Genome Res. 8 (11): 1097-108. PMID 9847074.
Loeffen JL, Triepels RH, van den Heuvel LP, et al. (1999). "cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed.". Biochem. Biophys. Res. Commun. 253 (2): 415-22. doi:10.1006/bbrc.1998.9786. PMID 9878551.
Tensing K, Pata I, Wittig I, et al. (1999). "Genomic organization of the human complex I 13-kDa subunit gene NDUFA5.". Cytogenet. Cell Genet. 84 (1-2): 125-7. PMID 10343126.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157-64. doi:10.1038/nature01782. PMID 12853948.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.