NDUFA2

From Wikipedia, the free encyclopedia

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa

PDB rendering based on 1s3a.

Available structures: 1s3a

Identifiers

Symbol(s)

NDUFA2; CD14; B8

External IDs

OMIM: 602137 MGI: 1343103 HomoloGene: 37628

Gene ontology
Molecular Function:	• NADH dehydrogenase activity • NADH dehydrogenase (ubiquinone) activity • oxidoreductase activity
Cellular Component:	• membrane fraction • mitochondrion
Biological Process:	• generation of precursor metabolites and energy

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002488 (mRNA)
NP_002479 (protein)

NM_010885 (mRNA)
NP_035015 (protein)

Location

Chr 5: 140.01 - 140.01 Mb

Chr 18: 36.87 - 36.87 Mb

Pubmed search

[1]

[2]

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa, also known as NDUFA2, is a human gene.^[1]

[edit] References

^ Entrez Gene: NDUFA2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa.

[edit] Further reading

Walker JE, Arizmendi JM, Dupuis A, et al. (1992). "Sequences of 20 subunits of NADH:ubiquinone oxidoreductase from bovine heart mitochondria. Application of a novel strategy for sequencing proteins using the polymerase chain reaction.". J. Mol. Biol. 226 (4): 1051–72. PMID 1518044.
Dunbar DR, Shibasaki Y, Dobbie L, et al. (1997). "In situ hybridisation mapping of genomic clones for five human respiratory chain complex I genes.". Cytogenet. Cell Genet. 78 (1): 21–4. PMID 9345899.
Ton C, Hwang DM, Dempsey AA, Liew CC (1998). "Identification and primary structure of five human NADH-ubiquinone oxidoreductase subunits.". Biochem. Biophys. Res. Commun. 241 (2): 589–94. doi:10.1006/bbrc.1997.7707. PMID 9425316.
Emahazion T, Brookes AJ (1998). "Mapping of the NDUFA2, NDUFA6, NDUFA7, NDUFB8, and NDUFS8 electron transport chain genes by intron based radiation hybrid mapping.". Cytogenet. Cell Genet. 82 (1-2): 114. PMID 9763676.
Loeffen JL, Triepels RH, van den Heuvel LP, et al. (1999). "cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed.". Biochem. Biophys. Res. Commun. 253 (2): 415–22. doi:10.1006/bbrc.1998.9786. PMID 9878551.
Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.". Genome Res. 10 (10): 1546–60. PMID 11042152.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Brockmann C, Diehl A, Rehbein K, et al. (2005). "The oxidized subunit B8 from human complex I adopts a thioredoxin fold.". Structure 12 (9): 1645–54. doi:10.1016/j.str.2004.06.021. PMID 15341729.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Vogel RO, Dieteren CE, van den Heuvel LP, et al. (2007). "Identification of mitochondrial complex I assembly intermediates by tracing tagged NDUFS3 demonstrates the entry point of mitochondrial subunits.". J. Biol. Chem. 282 (10): 7582–90. doi:10.1074/jbc.M609410200. PMID 17209039.