NDST2

From Wikipedia, the free encyclopedia

N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2

Identifiers

NDST2; HSST2; MGC129697; MGC129705; NCST2; NST2

External IDs

OMIM: 603268 MGI: 97040 HomoloGene: 20803

Gene ontology
Molecular Function:	• [heparan sulfate-glucosamine N-sulfotransferase activity] • transferase activity • hydrolase activity
Cellular Component:	• membrane • integral to membrane
Biological Process:	• heparan sulfate proteoglycan biosynthetic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003635 (mRNA)
NP_003626 (protein)

NM_010811 (mRNA)
NP_034941 (protein)

Location

Chr 10: 75.23 - 75.24 Mb

Chr 14: 19.51 - 19.52 Mb

Pubmed search

[1]

[2]

N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2, also known as NDST2, is a human gene.^[1]

[edit] References

^ Entrez Gene: NDST2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2.

[edit] Further reading

Esko JD, Selleck SB (2002). "Order out of chaos: assembly of ligand binding sites in heparan sulfate.". Annu. Rev. Biochem. 71: 435–71. doi:10.1146/annurev.biochem.71.110601.135458. PMID 12045103.
Humphries DE, Lanciotti J, Karlinsky JB (1998). "cDNA cloning, genomic organization and chromosomal localization of human heparan glucosaminyl N-deacetylase/N-sulphotransferase-2.". Biochem. J. 332 ( Pt 2): 303–7. PMID 9601056.
Aikawa J, Esko JD (1999). "Molecular cloning and expression of a third member of the heparan sulfate/heparin GlcNAc N-deacetylase/ N-sulfotransferase family.". J. Biol. Chem. 274 (5): 2690–5. PMID 9915799.
Forsberg E, Pejler G, Ringvall M, et al. (1999). "Abnormal mast cells in mice deficient in a heparin-synthesizing enzyme.". Nature 400 (6746): 773–6. doi:10.1038/23488. PMID 10466727.
Pikas DS, Eriksson I, Kjellén L (2000). "Overexpression of different isoforms of glucosaminyl N-deacetylase/N-sulfotransferase results in distinct heparan sulfate N-sulfation patterns.". Biochemistry 39 (15): 4552–8. PMID 10758005.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
van den Born J, Pikas DS, Pisa BJ, et al. (2003). "Antibody-based assay for N-deacetylase activity of heparan sulfate/heparin N-deacetylase/N-sulfotransferase (NDST): novel characteristics of NDST-1 and -2.". Glycobiology 13 (1): 1–10. doi:10.1093/glycob/cwg011. PMID 12634318.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Duncan MB, Liu M, Fox C, Liu J (2006). "Characterization of the N-deacetylase domain from the heparan sulfate N-deacetylase/N-sulfotransferase 2.". Biochem. Biophys. Res. Commun. 339 (4): 1232–7. doi:10.1016/j.bbrc.2005.11.142. PMID 16343444.