NDST1

From Wikipedia, the free encyclopedia

N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1

PDB rendering based on 1nst.

Available structures: 1nst

Identifiers

Symbol(s)

NDST1; HSST; NST1

External IDs

OMIM: 600853 MGI: 104719 HomoloGene: 20386

Gene ontology
Molecular Function:	• [heparan sulfate-glucosamine N-sulfotransferase activity] • transferase activity • hydrolase activity
Cellular Component:	• membrane • integral to membrane
Biological Process:	• protein amino acid deacetylation • protein amino acid sulfation • inflammatory response • heparan sulfate proteoglycan biosynthetic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001543 (mRNA)
NP_001534 (protein)

NM_008306 (mRNA)
NP_032332 (protein)

Location

Chr 5: 149.87 - 149.91 Mb

Chr 18: 60.81 - 60.84 Mb

Pubmed search

[1]

[2]

N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1, also known as NDST1, is a human gene.^[1]

[edit] References

^ Entrez Gene: NDST1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1.

[edit] Further reading

Dixon J, Loftus SK, Gladwin AJ, et al. (1995). "Cloning of the human heparan sulfate-N-deacetylase/N-sulfotransferase gene from the Treacher Collins syndrome candidate region at 5q32-q33.1.". Genomics 26 (2): 239–44. PMID 7601448.
Humphries DE, Sullivan BM, Aleixo MD, Stow JL (1997). "Localization of human heparan glucosaminyl N-deacetylase/N-sulphotransferase to the trans-Golgi network.". Biochem. J. 325 ( Pt 2): 351–7. PMID 9230113.
Sueyoshi T, Kakuta Y, Pedersen LC, et al. (1998). "A role of Lys614 in the sulfotransferase activity of human heparan sulfate N-deacetylase/N-sulfotransferase.". FEBS Lett. 433 (3): 211–4. PMID 9744796.
Aikawa J, Esko JD (1999). "Molecular cloning and expression of a third member of the heparan sulfate/heparin GlcNAc N-deacetylase/ N-sulfotransferase family.". J. Biol. Chem. 274 (5): 2690–5. PMID 9915799.
Kakuta Y, Sueyoshi T, Negishi M, Pedersen LC (1999). "Crystal structure of the sulfotransferase domain of human heparan sulfate N-deacetylase/ N-sulfotransferase 1.". J. Biol. Chem. 274 (16): 10673–6. PMID 10196134.
Pikas DS, Eriksson I, Kjellén L (2000). "Overexpression of different isoforms of glucosaminyl N-deacetylase/N-sulfotransferase results in distinct heparan sulfate N-sulfation patterns.". Biochemistry 39 (15): 4552–8. PMID 10758005.
Mura CV, Becker MI, Orellana A, Wolff D (2002). "Immunopurification of Golgi vesicles by magnetic sorting.". J. Immunol. Methods 260 (1-2): 263–71. PMID 11792394.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Bengtsson J, Eriksson I, Kjellén L (2003). "Distinct effects on heparan sulfate structure by different active site mutations in NDST-1.". Biochemistry 42 (7): 2110–5. doi:10.1021/bi026928g. PMID 12590599.
van den Born J, Pikas DS, Pisa BJ, et al. (2003). "Antibody-based assay for N-deacetylase activity of heparan sulfate/heparin N-deacetylase/N-sulfotransferase (NDST): novel characteristics of NDST-1 and -2.". Glycobiology 13 (1): 1–10. doi:10.1093/glycob/cwg011. PMID 12634318.
Nakayama K, Natori Y, Sato T, et al. (2004). "Altered expression of NDST-1 messenger RNA in puromycin aminonucleoside nephrosis.". J. Lab. Clin. Med. 143 (2): 106–14. doi:10.1016/j.lab.2003.10.012. PMID 14966466.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.