NDRG1

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N-myc downstream regulated gene 1
Identifiers
Symbol(s) NDRG1; DRG1; CAP43; CMT4D; GC4; HMSNL; NDR1; NMSL; PROXY1; RIT42; RTP; TARG1; TDD5
External IDs OMIM: 605262 MGI: 1341799 HomoloGene: 55953
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 10397 17988
Ensembl ENSG00000104419 n/a
Uniprot Q92597 n/a
Refseq NM_006096 (mRNA)
NP_006087 (protein)		 NM_008681 (mRNA)
NP_032707 (protein)
Location Chr 8: 134.32 - 134.38 Mb n/a
Pubmed search [1] [2]

N-myc downstream regulated gene 1, also known as NDRG1, is a human gene.[1]

This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein involved in stress responses, hormone responses, cell growth, and differentiation. Mutation in this gene has been reported to be causative for hereditary motor and sensory neuropathy-Lom.[1]

[edit] References

  1. ^ a b Entrez Gene: NDRG1 N-myc downstream regulated gene 1.

[edit] Further reading

  • Kovacevic Z, Richardson DR (2007). "The metastasis suppressor, Ndrg-1: a new ally in the fight against cancer.". Carcinogenesis 27 (12): 2355–66. doi:10.1093/carcin/bgl146. PMID 16920733. 
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298. 
  • Kalaydjieva L, Hallmayer J, Chandler D, et al. (1996). "Gene mapping in Gypsies identifies a novel demyelinating neuropathy on chromosome 8q24.". Nat. Genet. 14 (2): 214–7. doi:10.1038/ng1096-214. PMID 8841199. 
  • Kokame K, Kato H, Miyata T (1997). "Homocysteine-respondent genes in vascular endothelial cells identified by differential display analysis. GRP78/BiP and novel genes.". J. Biol. Chem. 271 (47): 29659–65. PMID 8939898. 
  • van Belzen N, Dinjens WN, Diesveld MP, et al. (1997). "A novel gene which is up-regulated during colon epithelial cell differentiation and down-regulated in colorectal neoplasms.". Lab. Invest. 77 (1): 85–92. PMID 9251681. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149. 
  • Zhou D, Salnikow K, Costa M (1998). "Cap43, a novel gene specifically induced by Ni2+ compounds.". Cancer Res. 58 (10): 2182–9. PMID 9605764. 
  • Kurdistani SK, Arizti P, Reimer CL, et al. (1998). "Inhibition of tumor cell growth by RTP/rit42 and its responsiveness to p53 and DNA damage.". Cancer Res. 58 (19): 4439–44. PMID 9766676. 
  • Piquemal D, Joulia D, Balaguer P, et al. (1999). "Differential expression of the RTP/Drg1/Ndr1 gene product in proliferating and growth arrested cells.". Biochim. Biophys. Acta 1450 (3): 364–73. PMID 10395947. 
  • Guan RJ, Ford HL, Fu Y, et al. (2000). "Drg-1 as a differentiation-related, putative metastatic suppressor gene in human colon cancer.". Cancer Res. 60 (3): 749–55. PMID 10676663. 
  • Kalaydjieva L, Gresham D, Gooding R, et al. (2000). "N-myc downstream-regulated gene 1 is mutated in hereditary motor and sensory neuropathy-Lom.". Am. J. Hum. Genet. 67 (1): 47–58. PMID 10831399. 
  • Park H, Adams MA, Lachat P, et al. (2000). "Hypoxia induces the expression of a 43-kDa protein (PROXY-1) in normal and malignant cells.". Biochem. Biophys. Res. Commun. 276 (1): 321–8. doi:10.1006/bbrc.2000.3475. PMID 11006124. 
  • Rutherford MN, Bayly GR, Matthews BP, et al. (2001). "The leukemogenic transcription factor E2a-Pbx1 induces expression of the putative N-myc and p53 target gene NDRG1 in Ba/F3 cells.". Leukemia 15 (3): 362–70. PMID 11237058. 
  • Zhou RH, Kokame K, Tsukamoto Y, et al. (2001). "Characterization of the human NDRG gene family: a newly identified member, NDRG4, is specifically expressed in brain and heart.". Genomics 73 (1): 86–97. doi:10.1006/geno.2000.6496. PMID 11352569. 
  • Qu X, Zhai Y, Wei H, et al. (2002). "Characterization and expression of three novel differentiation-related genes belong to the human NDRG gene family.". Mol. Cell. Biochem. 229 (1-2): 35–44. PMID 11936845. 
  • Cangul H, Salnikow K, Yee H, et al. (2002). "Enhanced expression of a novel protein in human cancer cells: a potential aid to cancer diagnosis.". Cell Biol. Toxicol. 18 (2): 87–96. PMID 12046693. 
  • Cangul H, Salnikow K, Yee H, et al. (2002). "Enhanced overexpression of an HIF-1/hypoxia-related protein in cancer cells.". Environ. Health Perspect. 110 Suppl 5: 783–8. PMID 12429530. 
  • Lachat P, Shaw P, Gebhard S, et al. (2003). "Expression of NDRG1, a differentiation-related gene, in human tissues.". Histochem. Cell Biol. 118 (5): 399–408. doi:10.1007/s00418-002-0460-9. PMID 12432451. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Segawa T, Nau ME, Xu LL, et al. (2003). "Androgen-induced expression of endoplasmic reticulum (ER) stress response genes in prostate cancer cells.". Oncogene 21 (57): 8749–58. doi:10.1038/sj.onc.1205992. PMID 12483528. 
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