NDEL1
From Wikipedia, the free encyclopedia
NudE nuclear distribution gene E homolog (A. nidulans)-like 1
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Identifiers | ||||||||||||||
Symbol(s) | NDEL1; DKFZp451M0318; EOPA; MITAP1; NUDEL | |||||||||||||
External IDs | OMIM: 607538 MGI: 1932915 HomoloGene: 32567 | |||||||||||||
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RNA expression pattern | ||||||||||||||
Orthologs | ||||||||||||||
Human | Mouse | |||||||||||||
Entrez | 81565 | 83431 | ||||||||||||
Ensembl | ENSG00000166579 | ENSMUSG00000018736 | ||||||||||||
Uniprot | Q9GZM8 | Q9ERR1 | ||||||||||||
Refseq | NM_001025579 (mRNA) NP_001020750 (protein) |
NM_023668 (mRNA) NP_076157 (protein) |
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Location | Chr 17: 8.28 - 8.32 Mb | Chr 11: 68.64 - 68.69 Mb | ||||||||||||
Pubmed search | [1] | [2] |
NudE nuclear distribution gene E homolog (A. nidulans)-like 1, also known as NDEL1, is a human gene.[1]
This gene encodes a thiol-activated peptidase that is phosphorylated in M phase of the cell cycle. Phosphorylation regulates the cell cycle-dependent distribution of this protein, with a fraction of the protein bound strongly to centrosomes in interphase and localized to mitotic spindles in early M phase. Overall, this protein plays a role in nervous system development. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[1]
[edit] References
[edit] Further reading
- Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. doi: . PMID 8619474.
- Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. PMID 9110174.
- Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. PMID 10737800.
- Feng Y, Olson EC, Stukenberg PT, et al. (2001). "LIS1 regulates CNS lamination by interacting with mNudE, a central component of the centrosome.". Neuron 28 (3): 665–79. PMID 11163258.
- Sasaki S, Shionoya A, Ishida M, et al. (2001). "A LIS1/NUDEL/cytoplasmic dynein heavy chain complex in the developing and adult nervous system.". Neuron 28 (3): 681–96. PMID 11163259.
- Niethammer M, Smith DS, Ayala R, et al. (2001). "NUDEL is a novel Cdk5 substrate that associates with LIS1 and cytoplasmic dynein.". Neuron 28 (3): 697–711. PMID 11163260.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi: . PMID 12477932.
- Ozeki Y, Tomoda T, Kleiderlein J, et al. (2003). "Disrupted-in-Schizophrenia-1 (DISC-1): mutant truncation prevents binding to NudE-like (NUDEL) and inhibits neurite outgrowth.". Proc. Natl. Acad. Sci. U.S.A. 100 (1): 289–94. doi: . PMID 12506198.
- Yan X, Li F, Liang Y, et al. (2003). "Human Nudel and NudE as regulators of cytoplasmic dynein in poleward protein transport along the mitotic spindle.". Mol. Cell. Biol. 23 (4): 1239–50. PMID 12556484.
- Cardoso C, Leventer RJ, Ward HL, et al. (2003). "Refinement of a 400-kb critical region allows genotypic differentiation between isolated lissencephaly, Miller-Dieker syndrome, and other phenotypes secondary to deletions of 17p13.3.". Am. J. Hum. Genet. 72 (4): 918–30. PMID 12621583.
- Toyo-oka K, Shionoya A, Gambello MJ, et al. (2003). "14-3-3epsilon is important for neuronal migration by binding to NUDEL: a molecular explanation for Miller-Dieker syndrome.". Nat. Genet. 34 (3): 274–85. doi: . PMID 12796778.
- Morris JA, Kandpal G, Ma L, Austin CP (2004). "DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation.". Hum. Mol. Genet. 12 (13): 1591–608. PMID 12812986.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi: . PMID 14702039.
- Brandon NJ, Handford EJ, Schurov I, et al. (2004). "Disrupted in Schizophrenia 1 and Nudel form a neurodevelopmentally regulated protein complex: implications for schizophrenia and other major neurological disorders.". Mol. Cell. Neurosci. 25 (1): 42–55. doi: . PMID 14962739.
- Liang Y, Yu W, Li Y, et al. (2004). "Nudel functions in membrane traffic mainly through association with Lis1 and cytoplasmic dynein.". J. Cell Biol. 164 (4): 557–66. doi: . PMID 14970193.
- Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.". Genome Res. 14 (9): 1711–8. doi: . PMID 15342556.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi: . PMID 15489334.
- Tarricone C, Perrina F, Monzani S, et al. (2005). "Coupling PAF signaling to dynein regulation: structure of LIS1 in complex with PAF-acetylhydrolase.". Neuron 44 (5): 809–21. doi: . PMID 15572112.
- Hayashi MA, Portaro FC, Bastos MF, et al. (2005). "Inhibition of NUDEL (nuclear distribution element-like)-oligopeptidase activity by disrupted-in-schizophrenia 1.". Proc. Natl. Acad. Sci. U.S.A. 102 (10): 3828–33. doi: . PMID 15728732.
- Guerreiro JR, Winnischofer SM, Bastos MF, et al. (2005). "Cloning and characterization of the human and rabbit NUDEL-oligopeptidase promoters and their negative regulation.". Biochim. Biophys. Acta 1730 (1): 77–84. doi: . PMID 16005531.