NDC80

From Wikipedia, the free encyclopedia

NDC80 homolog, kinetochore complex component (S. cerevisiae)

PDB rendering based on 2igp.

Available structures: 2igp

Identifiers

Symbol(s)

NDC80; HEC; HEC1; KNTC2; TID3; hsNDC80

External IDs

OMIM: 607272 MGI: 1914302 HomoloGene: 38141

Gene ontology
Molecular Function:	• protein binding
Cellular Component:	• chromosome, pericentric region • nucleus
Biological Process:	• mitotic sister chromatid segregation • cell cycle • spindle organization and biogenesis • phosphoinositide-mediated signaling • cell division

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_006101 (mRNA)
NP_006092 (protein)

NM_023294 (mRNA)
NP_075783 (protein)

Location

Chr 18: 2.56 - 2.61 Mb

Chr 17: 71.4 - 71.43 Mb

Pubmed search

[1]

[2]

NDC80 homolog, kinetochore complex component (S. cerevisiae), also known as NDC80, is a human gene.^[1]

HEC is one of several proteins involved in spindle checkpoint signaling. This surveillance mechanism assures correct segregation of chromosomes during cell division by detecting unaligned chromosomes and causing prometaphase arrest until the proper bipolar attachment of chromosomes is achieved.[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: NDC80 NDC80 homolog, kinetochore complex component (S. cerevisiae).

[edit] Further reading

Chen Y, Sharp ZD, Lee WH (1997). "HEC binds to the seventh regulatory subunit of the 26 S proteasome and modulates the proteolysis of mitotic cyclins.". J. Biol. Chem. 272 (38): 24081–7. PMID 9295362.
Chen Y, Riley DJ, Chen PL, Lee WH (1997). "HEC, a novel nuclear protein rich in leucine heptad repeats specifically involved in mitosis.". Mol. Cell. Biol. 17 (10): 6049–56. PMID 9315664.
Zheng L, Chen Y, Lee WH (1999). "Hec1p, an evolutionarily conserved coiled-coil protein, modulates chromosome segregation through interaction with SMC proteins.". Mol. Cell. Biol. 19 (8): 5417–28. PMID 10409732.
Zheng L, Chen Y, Riley DJ, et al. (2000). "Retinoblastoma protein enhances the fidelity of chromosome segregation mediated by hsHec1p.". Mol. Cell. Biol. 20 (10): 3529–37. PMID 10779342.
Martin-Lluesma S, Stucke VM, Nigg EA (2002). "Role of Hec1 in spindle checkpoint signaling and kinetochore recruitment of Mad1/Mad2.". Science 297 (5590): 2267–70. doi:10.1126/science.1075596. PMID 12351790.
Chen Y, Riley DJ, Zheng L, et al. (2003). "Phosphorylation of the mitotic regulator protein Hec1 by Nek2 kinase is essential for faithful chromosome segregation.". J. Biol. Chem. 277 (51): 49408–16. doi:10.1074/jbc.M207069200. PMID 12386167.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Tien AC, Lin MH, Su LJ, et al. (2004). "Identification of the substrates and interaction proteins of aurora kinases from a protein-protein interaction model.". Mol. Cell Proteomics 3 (1): 93–104. doi:10.1074/mcp.M300072-MCP200. PMID 14602875.
DeLuca JG, Howell BJ, Canman JC, et al. (2004). "Nuf2 and Hec1 are required for retention of the checkpoint proteins Mad1 and Mad2 to kinetochores.". Curr. Biol. 13 (23): 2103–9. PMID 14654001.
Bharadwaj R, Qi W, Yu H (2004). "Identification of two novel components of the human NDC80 kinetochore complex.". J. Biol. Chem. 279 (13): 13076–85. doi:10.1074/jbc.M310224200. PMID 14699129.
Lou Y, Yao J, Zereshki A, et al. (2004). "NEK2A interacts with MAD1 and possibly functions as a novel integrator of the spindle checkpoint signaling.". J. Biol. Chem. 279 (19): 20049–57. doi:10.1074/jbc.M314205200. PMID 14978040.
Joseph J, Liu ST, Jablonski SA, et al. (2004). "The RanGAP1-RanBP2 complex is essential for microtubule-kinetochore interactions in vivo.". Curr. Biol. 14 (7): 611–7. doi:10.1016/j.cub.2004.03.031. PMID 15062103.
Steensgaard P, Garrè M, Muradore I, et al. (2005). "Sgt1 is required for human kinetochore assembly.". EMBO Rep. 5 (6): 626–31. doi:10.1038/sj.embor.7400154. PMID 15133482.
Stucke VM, Baumann C, Nigg EA (2005). "Kinetochore localization and microtubule interaction of the human spindle checkpoint kinase Mps1.". Chromosoma 113 (1): 1–15. doi:10.1007/s00412-004-0288-2. PMID 15235793.
Meraldi P, Draviam VM, Sorger PK (2004). "Timing and checkpoints in the regulation of mitotic progression.". Dev. Cell 7 (1): 45–60. doi:10.1016/j.devcel.2004.06.006. PMID 15239953.
Cheeseman IM, Niessen S, Anderson S, et al. (2004). "A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension.". Genes Dev. 18 (18): 2255–68. doi:10.1101/gad.1234104. PMID 15371340.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Obuse C, Iwasaki O, Kiyomitsu T, et al. (2004). "A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1.". Nat. Cell Biol. 6 (11): 1135–41. doi:10.1038/ncb1187. PMID 15502821.
Le XF, Lammayot A, Gold D, et al. (2005). "Genes affecting the cell cycle, growth, maintenance, and drug sensitivity are preferentially regulated by anti-HER2 antibody through phosphatidylinositol 3-kinase-AKT signaling.". J. Biol. Chem. 280 (3): 2092–104. doi:10.1074/jbc.M403080200. PMID 15504738.
DeLuca JG, Dong Y, Hergert P, et al. (2005). "Hec1 and nuf2 are core components of the kinetochore outer plate essential for organizing microtubule attachment sites.". Mol. Biol. Cell 16 (2): 519–31. doi:10.1091/mbc.E04-09-0852. PMID 15548592.