NCOA5

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Nuclear receptor coactivator 5
PDB rendering based on 1v95.
Available structures: 1v95
Identifiers
Symbol(s) NCOA5; CIA; bA465L10.6
External IDs MGI: 2385165 HomoloGene: 32496
Orthologs
Human Mouse
Entrez 57727 228869
Ensembl ENSG00000124160 ENSMUSG00000039804
Uniprot Q9HCD5 Q8BX12
Refseq NM_020967 (mRNA)
NP_066018 (protein)		 NM_144892 (mRNA)
NP_659141 (protein)
Location Chr 20: 44.12 - 44.15 Mb Chr 2: 164.69 - 164.73 Mb
Pubmed search [1] [2]

Nuclear receptor coactivator 5, also known as NCOA5, is a human gene.[1]

This gene encodes a coregulator for the alpha and beta estrogen receptors and the orphan nuclear receptor NR1D2. The protein localizes to the nucleus, and is thought to have both coactivator and corepressor functions. Its interaction with nuclear receptors is independent of the AF2 domain on the receptors, which is known to regulate interaction with other coreceptors. Two alternatively spliced transcript variants for this gene have been described. However, the full length nature of one of the variants has not been determined.[1]

[edit] References

  1. ^ a b Entrez Gene: NCOA5 nuclear receptor coactivator 5.

[edit] Further reading

  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635-48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. 
  • Tao WA, Wollscheid B, O'Brien R, et al. (2005). "Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry.". Nat. Methods 2 (8): 591-8. doi:10.1038/nmeth776. PMID 16094384. 
  • Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707-16. doi:10.1038/nbt971. PMID 15146197. 
  • Jiang C, Ito M, Piening V, et al. (2004). "TIP30 interacts with an estrogen receptor alpha-interacting coactivator CIA and regulates c-myc transcription.". J. Biol. Chem. 279 (26): 27781-9. doi:10.1074/jbc.M401809200. PMID 15073177. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865-71. doi:10.1038/414865a. PMID 11780052. 
  • Sauvé F, McBroom LD, Gallant J, et al. (2001). "CIA, a novel estrogen receptor coactivator with a bifunctional nuclear receptor interacting determinant.". Mol. Cell. Biol. 21 (1): 343-53. doi:10.1128/MCB.21.1.343-353.2001. PMID 11113208. 
  • Nagase T, Kikuno R, Nakayama M, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 7 (4): 273-81. PMID 10997877. 

[edit] External links

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v • d • e
Transcription coregulators
Coactivators
ARA54 - ARA55 - CARM1 - CRTC1 - CRTC2 - CBP - PPARGC1A - PPARGC1B - TGFB1I1
NCOA1 (SRC-1) - NCOA2 (GRIP1/SRC-2/TIF2) - NCOA3 (AIB/SRC-3/TRAM-1) - NCOA4 (ARA70) - NCOA5 (CIA) - NCOA6 (RAP250) - NCOA7 (ERAP140)
Corepressors
Hairless homolog - NRIP1 - PELP-1 - RCOR1 - Rb - SIN3A - SIN3B - Tripartite motif-containing (TRIM24, TRIM28, TRIM33)
NCOR1 - NCOR2 (SMRT)
ATP-dependent remodeling factors