NCKAP1

From Wikipedia, the free encyclopedia

NCK-associated protein 1

Identifiers

NCKAP1; NAP1; FLJ11291; HEM2; KIAA0587; MGC8981; NAP125

External IDs

OMIM: 604891 MGI: 1355333 HomoloGene: 8384

Gene ontology
Molecular Function:	• protein binding
Cellular Component:	• membrane • integral to membrane
Biological Process:	• apoptosis • central nervous system development

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_013436 (mRNA)
NP_038464 (protein)

NM_016965 (mRNA)
NP_058661 (protein)

Location

Chr 2: 183.5 - 183.61 Mb

Chr 2: 80.3 - 80.38 Mb

Pubmed search

[1]

[2]

NCK-associated protein 1, also known as NCKAP1, is a human gene.^[1]

[edit] References

^ Entrez Gene: NCKAP1 NCK-associated protein 1.

[edit] Further reading

Kitamura T, Kitamura Y, Yonezawa K, et al. (1996). "Molecular cloning of p125Nap1, a protein that associates with an SH3 domain of Nck.". Biochem. Biophys. Res. Commun. 219 (2): 509-14. PMID 8605018.
Kitamura Y, Kitamura T, Sakaue H, et al. (1997). "Interaction of Nck-associated protein 1 with activated GTP-binding protein Rac.". Biochem. J. 322 ( Pt 3): 873-8. PMID 9148763.
Kobayashi K, Kuroda S, Fukata M, et al. (1998). "p140Sra-1 (specifically Rac1-associated protein) is a novel specific target for Rac1 small GTPase.". J. Biol. Chem. 273 (1): 291-5. PMID 9417078.
Witke W, Podtelejnikov AV, Di Nardo A, et al. (1998). "In mouse brain profilin I and profilin II associate with regulators of the endocytic pathway and actin assembly.". EMBO J. 17 (4): 967-76. doi:10.1093/emboj/17.4.967. PMID 9463375.
Nagase T, Ishikawa K, Miyajima N, et al. (1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.". DNA Res. 5 (1): 31-9. PMID 9628581.
Suzuki T, Nishiyama K, Yamamoto A, et al. (2000). "Molecular cloning of a novel apoptosis-related gene, human Nap1 (NCKAP1), and its possible relation to Alzheimer disease.". Genomics 63 (2): 246-54. doi:10.1006/geno.1999.6053. PMID 10673335.
Yamamoto A, Suzuki T, Sakaki Y (2001). "Isolation of hNap1BP which interacts with human Nap1 (NCKAP1) whose expression is down-regulated in Alzheimer's disease.". Gene 271 (2): 159-69. PMID 11418237.
Eden S, Rohatgi R, Podtelejnikov AV, et al. (2002). "Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck.". Nature 418 (6899): 790-3. doi:10.1038/nature00859. PMID 12181570.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Salazar MA, Kwiatkowski AV, Pellegrini L, et al. (2004). "Tuba, a novel protein containing bin/amphiphysin/Rvs and Dbl homology domains, links dynamin to regulation of the actin cytoskeleton.". J. Biol. Chem. 278 (49): 49031-43. doi:10.1074/jbc.M308104200. PMID 14506234.
Fujita F, Taniguchi Y, Kato T, et al. (2003). "Identification of NAP1, a regulatory subunit of IkappaB kinase-related kinases that potentiates NF-kappaB signaling.". Mol. Cell. Biol. 23 (21): 7780-93. PMID 14560022.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Innocenti M, Zucconi A, Disanza A, et al. (2004). "Abi1 is essential for the formation and activation of a WAVE2 signalling complex.". Nat. Cell Biol. 6 (4): 319-27. doi:10.1038/ncb1105. PMID 15048123.
Mayne M, Moffatt T, Kong H, et al. (2004). "CYFIP2 is highly abundant in CD4+ cells from multiple sclerosis patients and is involved in T cell adhesion.". Eur. J. Immunol. 34 (4): 1217-27. doi:10.1002/eji.200324726. PMID 15048733.
Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.". Curr. Biol. 14 (16): 1436-50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Chen W, Tang Z, Fortina P, et al. (2005). "Ethanol potentiates HIV-1 gp120-induced apoptosis in human neurons via both the death receptor and NMDA receptor pathways.". Virology 334 (1): 59-73. doi:10.1016/j.virol.2005.01.014. PMID 15749123.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.