NCDN

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Neurochondrin
Identifiers
Symbol(s) NCDN; KIAA0607
External IDs OMIM: 608458 MGI: 1347351 HomoloGene: 8064
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 23154 26562
Ensembl ENSG00000020129 ENSMUSG00000028833
Refseq NM_001014839 (mRNA)
NP_001014839 (protein)		 NM_011986 (mRNA)
NP_036116 (protein)
Location Chr 1: 35.8 - 35.8 Mb Chr 4: 126.25 - 126.26 Mb
Pubmed search [1] [2]

Neurochondrin, also known as NCDN, is a human gene.[1]

This gene encodes a leucine-rich cytoplasmic protein, which is highly similar to a mouse protein that negatively regulates Ca/calmodulin-dependent protein kinase II phosphorylation and may be essential for spatial learning processes. Several alternatively spliced transcript variants of this gene have been described.[1]

[edit] References

  1. ^ a b Entrez Gene: NCDN neurochondrin.

[edit] Further reading

  • Dateki M, Horii T, Kasuya Y, et al. (2005). "Neurochondrin negatively regulates CaMKII phosphorylation, and nervous system-specific gene disruption results in epileptic seizure.". J. Biol. Chem. 280 (21): 20503–8. doi:10.1074/jbc.M414033200. PMID 15790563. 
  • Mochizuki R, Dateki M, Yanai K, et al. (2003). "Targeted disruption of the neurochondrin/norbin gene results in embryonic lethality.". Biochem. Biophys. Res. Commun. 310 (4): 1219–26. PMID 14559245. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Tchernev VT, Mansfield TA, Giot L, et al. (2002). "The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins.". Mol. Med. 8 (1): 56–64. PMID 11984006. 
  • Ohoka Y, Hirotani M, Sugimoto H, et al. (2001). "Semaphorin 4C, a transmembrane semaphorin, [corrected] associates with a neurite-outgrowth-related protein, SFAP75.". Biochem. Biophys. Res. Commun. 280 (1): 237–43. doi:10.1006/bbrc.2000.4080. PMID 11162505. 
  • Mochizuki R, Ishizuka Y, Yanai K, et al.. "Corrigendum to 'Molecular cloning and expression of human neurochondrin-1 and -2'(1).". Biochim. Biophys. Acta 1490 (3): 367–8. PMID 10684983. 
  • Mochizuki R, Ishizuka Y, Yanai K, et al. (1999). "Molecular cloning and expression of human neurochondrin-1 and -2.". Biochim. Biophys. Acta 1446 (3): 397–402. PMID 10524216. 
  • Nagase T, Ishikawa K, Miyajima N, et al. (1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.". DNA Res. 5 (1): 31–9. PMID 9628581. 
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