NCAPH

From Wikipedia, the free encyclopedia


Non-SMC condensin I complex, subunit H
Identifiers
Symbol(s) NCAPH; BRRN1; CAP-H; HCAP-H
External IDs OMIM: 602332 MGI: 2444777 HomoloGene: 5320
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 23397 215387
Ensembl ENSG00000121152 ENSMUSG00000034906
Uniprot Q15003 Q6ZQJ9
Refseq NM_015341 (mRNA)
NP_056156 (protein)		 NM_144818 (mRNA)
NP_659067 (protein)
Location Chr 2: 96.37 - 96.41 Mb Chr 2: 126.8 - 126.83 Mb
Pubmed search [1] [2]

Non-SMC condensin I complex, subunit H, also known as NCAPH, is a human gene.[1]

This gene encodes a member of the barr gene family and a regulatory subunit of the condensin complex. This complex is required for the conversion of interphase chromatin into condensed chromosomes. The protein encoded by this gene is associated with mitotic chromosomes, except during the early phase of chromosome condensation. During interphase, the protein has a distinct punctate nucleolar localization.[1]

[edit] References

  1. ^ a b Entrez Gene: NCAPH non-SMC condensin I complex, subunit H.

[edit] Further reading

  • Nomura N, Nagase T, Miyajima N, et al. (1995). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1.". DNA Res. 1 (5): 223–9. PMID 7584044. 
  • Hirano T, Kobayashi R, Hirano M (1997). "Condensins, chromosome condensation protein complexes containing XCAP-C, XCAP-E and a Xenopus homolog of the Drosophila Barren protein.". Cell 89 (4): 511–21. PMID 9160743. 
  • Cabello OA, Baldini A, Bhat M, et al. (1998). "Localization of BRRN1, the human homologue of Drosophila barr, to 2q11.2.". Genomics 46 (2): 311–3. doi:10.1006/geno.1997.5021. PMID 9417923. 
  • Kimura K, Cuvier O, Hirano T (2001). "Chromosome condensation by a human condensin complex in Xenopus egg extracts.". J. Biol. Chem. 276 (8): 5417–20. doi:10.1074/jbc.C000873200. PMID 11136719. 
  • Cabello OA, Eliseeva E, He WG, et al. (2002). "Cell cycle-dependent expression and nucleolar localization of hCAP-H.". Mol. Biol. Cell 12 (11): 3527–37. PMID 11694586. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Heale JT, Ball AR, Schmiesing JA, et al. (2006). "Condensin I interacts with the PARP-1-XRCC1 complex and functions in DNA single-strand break repair.". Mol. Cell 21 (6): 837–48. doi:10.1016/j.molcel.2006.01.036. PMID 16543152. 
  • Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle.". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMID 16565220. 
  • Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. 
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