NBQX
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| NBQX | |
|---|---|
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| IUPAC name | 6-nitro-2,3-dioxo-1,4-dihydrobenzo [f]quinoxaline-7-sulfonamide |
| Identifiers | |
| CAS number | [118876-58-7] |
| PubChem | |
| SMILES | C1=CC2=C3C(=CC(=C2C(=C1)S (=O)(=O)N)[N+](=O)[O-])NC(=O)C(=O)N3 |
| Properties | |
| Molecular formula | C12H8N4O6S |
| Molar mass | 336.281 |
| Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox disclaimer and references |
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NBQX (2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo[f]quinoxaline-2,3-dione) is an AMPA receptor antagonist brown/red powder.
Disodium salt version can be dissolved in water at higher concentrations (<30 mmol).
Blocks AMPA receptors in micromolar concentrations (~10–20 µmol) and also kainate receptors. In experiments it is used to counter glutamate excitotoxicity.[1]
[edit] References
- ^ Pitt, D.; Werner, P.; Raine, C. S. (2000). "Glutamate excitotoxicity in a model of multiple sclerosis". Nat Med. 6 (1): 67–70.
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