NAV2

From Wikipedia, the free encyclopedia

Neuron navigator 2

Identifiers

NAV2; FLJ10633; FLJ11030; FLJ23707; HELAD1; KIAA1419; POMFIL2; RAINB1; STEERIN2

External IDs

Gene ontology
Molecular Function:	• nucleotide binding • helicase activity • ATP binding • hydrolase activity • nucleoside-triphosphatase activity
Cellular Component:	• nucleus

Orthologs

Human

Mouse

Entrez

89797

n/a

Refseq

NM_145117 (mRNA)
NP_660093 (protein)

n/a (mRNA)
n/a (protein)

Pubmed search

[1]

n/a

Neuron navigator 2, also known as NAV2, is a human gene.^[1]

The vitamin A metabolite, all-trans retinoic acid (atRA), plays an important role in neuronal development, including neurite outgrowth. RAINB1 is an atRA-responsive gene.[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: NAV2 neuron navigator 2.

[edit] Further reading

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Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags.". Genome Res. 6 (9): 807–28. PMID 8889549.
Nagase T, Kikuno R, Ishikawa KI, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 7 (1): 65–73. PMID 10718198.
Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. PMID 10737800.
Merrill RA, Plum LA, Kaiser ME, Clagett-Dame M (2002). "A mammalian homolog of unc-53 is regulated by all-trans retinoic acid in neuroblastoma cells and embryos.". Proc. Natl. Acad. Sci. U.S.A. 99 (6): 3422–7. doi:10.1073/pnas.052017399. PMID 11904404.
Coy JF, Wiemann S, Bechmann I, et al. (2002). "Pore membrane and/or filament interacting like protein 1 (POMFIL1) is predominantly expressed in the nervous system and encodes different protein isoforms.". Gene 290 (1-2): 73–94. PMID 12062803.
Maes T, Barceló A, Buesa C (2003). "Neuron navigator: a human gene family with homology to unc-53, a cell guidance gene from Caenorhabditis elegans.". Genomics 80 (1): 21–30. PMID 12079279.
Ishiguro H, Shimokawa T, Tsunoda T, et al. (2002). "Isolation of HELAD1, a novel human helicase gene up-regulated in colorectal carcinomas.". Oncogene 21 (41): 6387–94. doi:10.1038/sj.onc.1205751. PMID 12214280.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Mitin NY, Ramocki MB, Zullo AJ, et al. (2004). "Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization.". J. Biol. Chem. 279 (21): 22353–61. doi:10.1074/jbc.M312867200. PMID 15031288.
Tsutsumi S, Kamata N, Vokes TJ, et al. (2004). "The novel gene encoding a putative transmembrane protein is mutated in gnathodiaphyseal dysplasia (GDD).". Am. J. Hum. Genet. 74 (6): 1255–61. doi:10.1086/421527. PMID 15124103.
Peeters PJ, Baker A, Goris I, et al. (2004). "Sensory deficits in mice hypomorphic for a mammalian homologue of unc-53.". Brain Res. Dev. Brain Res. 150 (2): 89–101. doi:10.1016/j.devbrainres.2004.03.004. PMID 15158073.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.