NAV1

From Wikipedia, the free encyclopedia


Neuron navigator 1
Identifiers
Symbol(s) NAV1; DKFZp781D0314; FLJ12560; FLJ14203; KIAA1151; MGC14961; POMFIL3; steerin-1
External IDs MGI: 2183683 HomoloGene: 10719
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 89796 215690
Ensembl ENSG00000134369 ENSMUSG00000009418
Refseq NM_020443 (mRNA)
NP_065176 (protein)		 NM_173437 (mRNA)
NP_775613 (protein)
Location Chr 1: 199.86 - 200.06 Mb Chr 1: 137.26 - 137.42 Mb
Pubmed search [1] [2]

Neuron navigator 1, also known as NAV1, is a human gene.[1]

This gene belongs to the neuron navigator family and is expressed predominantly in the nervous system. The encoded protein contains coiled-coil domains and a conserved AAA domain characteristic for ATPases associated with a variety of cellular activities. This gene is similar to unc-53, a Caenorhabditis elegans gene involved in axon guidance. The exact function of this gene is not known.[1]

[edit] References

  1. ^ a b Entrez Gene: NAV1 neuron navigator 1.

[edit] Further reading

  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55-65. doi:10.1101/gr.4039406. PMID 16344560. 
  • Peeters PJ, Baker A, Goris I, et al. (2004). "Sensory deficits in mice hypomorphic for a mammalian homologue of unc-53.". Brain Res. Dev. Brain Res. 150 (2): 89-101. doi:10.1016/j.devbrainres.2004.03.004. PMID 15158073. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. 
  • Okazaki N, Kikuno R, Ohara R, et al. (2003). "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.". DNA Res. 10 (1): 35-48. PMID 12693553. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.". Genome Res. 12 (11): 1773-84. doi:10.1101/gr.406902. PMID 12421765. 
  • Maes T, Barceló A, Buesa C (2003). "Neuron navigator: a human gene family with homology to unc-53, a cell guidance gene from Caenorhabditis elegans.". Genomics 80 (1): 21-30. PMID 12079279. 
  • Coy JF, Wiemann S, Bechmann I, et al. (2002). "Pore membrane and/or filament interacting like protein 1 (POMFIL1) is predominantly expressed in the nervous system and encodes different protein isoforms.". Gene 290 (1-2): 73-94. PMID 12062803. 
  • Nagase T, Ishikawa K, Kikuno R, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 6 (5): 337-45. PMID 10574462. 
  • Hirosawa M, Nagase T, Ishikawa K, et al. (2000). "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain.". DNA Res. 6 (5): 329-36. PMID 10574461. 
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