NASP (gene)

From Wikipedia, the free encyclopedia

Nuclear autoantigenic sperm protein (histone-binding)

Identifiers

NASP; DKFZp547F162; FLB7527; FLJ31599; FLJ35510; MGC19722; MGC20372; MGC2297; PRO1999

External IDs

OMIM: 603185 MGI: 1355328 HomoloGene: 1856

Gene ontology
Molecular Function:	• binding • Hsp90 protein binding
Cellular Component:	• nucleus
Biological Process:	• blastocyst development • DNA replication • cell cycle • cell proliferation • protein transport • histone exchange

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002482 (mRNA)
NP_002473 (protein)

NM_001081475 (mRNA)
NP_001074944 (protein)

Location

Chr 1: 45.82 - 45.86 Mb

Chr 4: 116.1 - 116.13 Mb

Pubmed search

[1]

[2]

Nuclear autoantigenic sperm protein (histone-binding), also known as NASP, is a human gene.^[1]

This gene encodes a H1 histone binding protein that is involved in transporting histones into the nucleus of dividing cells. Multiple isoforms are encoded by transcript variants of this gene. The somatic form is expressed in all mitotic cells, is localized to the nucleus, and is coupled to the cell cycle. The testicular form is expressed in embryonic tissues, tumor cells, and the testis. In male germ cells, this protein is localized to the cytoplasm of primary spermatocytes, the nucleus of spermatids, and the periacrosomal region of mature spermatozoa.^[1]

[edit] References

^ ^a ^b Entrez Gene: NASP nuclear autoantigenic sperm protein (histone-binding).

[edit] Further reading

O'Rand MG, Richardson RT, Zimmerman LJ, Widgren EE (1992). "Sequence and localization of human NASP: conservation of a Xenopus histone-binding protein.". Dev. Biol. 154 (1): 37–44. PMID 1426632.
Welch JE, Zimmerman LJ, Joseph DR, O'Rand MG (1991). "Characterization of a sperm-specific nuclear autoantigenic protein. I. Complete sequence and homology with the Xenopus protein, N1/N2.". Biol. Reprod. 43 (4): 559–68. PMID 2289010.
Welch JE, O'Rand MG (1991). "Characterization of a sperm-specific nuclear autoantigenic protein. II. Expression and localization in the testis.". Biol. Reprod. 43 (4): 569–78. PMID 2289011.
Kleinschmidt JA, Dingwall C, Maier G, Franke WW (1987). "Molecular characterization of a karyophilic, histone-binding protein: cDNA cloning, amino acid sequence and expression of nuclear protein N1/N2 of Xenopus laevis.". EMBO J. 5 (13): 3547–52. PMID 3549279.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Lee YH, O'Rand MG (1993). "Ultrastructural localization of a nuclear autoantigenic sperm protein in spermatogenic cells and spermatozoa.". Anat. Rec. 236 (3): 442–8. doi:10.1002/ar.1092360304. PMID 8363049.
Batova I, O'Rand MG (1996). "Histone-binding domains in a human nuclear autoantigenic sperm protein.". Biol. Reprod. 54 (6): 1238–44. PMID 8724350.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Richardson RT, Batova IN, Widgren EE, et al. (2000). "Characterization of the histone H1-binding protein, NASP, as a cell cycle-regulated somatic protein.". J. Biol. Chem. 275 (39): 30378–86. doi:10.1074/jbc.M003781200. PMID 10893414.
Batova IN, Richardson RT, Widgren EE, O'Rand MG (2000). "Analysis of the autoimmune epitopes on human testicular NASP using recombinant and synthetic peptides.". Clin. Exp. Immunol. 121 (2): 201–9. PMID 10931132.
Minami N, Sasaki K, Aizawa A, et al. (2001). "Analysis of gene expression in mouse 2-cell embryos using fluorescein differential display: comparison of culture environments.". Biol. Reprod. 64 (1): 30–5. PMID 11133655.
Richardson RT, Bencic DC, O'Rand MG (2001). "Comparison of mouse and human NASP genes and expression in human transformed and tumor cell lines.". Gene 274 (1-2): 67–75. PMID 11674998.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Alekseev OM, Bencic DC, Richardson RT, et al. (2003). "Overexpression of the Linker histone-binding protein tNASP affects progression through the cell cycle.". J. Biol. Chem. 278 (10): 8846–52. doi:10.1074/jbc.M210352200. PMID 12509435.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Silva AP, Chen J, Carraro DM, et al. (2004). "Generation of longer 3' cDNA fragments from massively parallel signature sequencing tags.". Nucleic Acids Res. 32 (12): e94. doi:10.1093/nar/gnh095. PMID 15247327.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Groth A, Ray-Gallet D, Quivy JP, et al. (2005). "Human Asf1 regulates the flow of S phase histones during replicational stress.". Mol. Cell 17 (2): 301–11. doi:10.1016/j.molcel.2004.12.018. PMID 15664198.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.