NARS (gene)

From Wikipedia, the free encyclopedia

Asparaginyl-tRNA synthetase

Identifiers

NARS; ASNRS; NARS1

External IDs

OMIM: 108410 MGI: 1917473 HomoloGene: 68404

Gene ontology
Molecular Function:	• nucleotide binding • nucleic acid binding • DNA-directed DNA polymerase activity • aspartate-tRNA ligase activity • asparagine-tRNA ligase activity • protein binding • ATP binding • transferase activity • ligase activity
Cellular Component:	• soluble fraction • cytoplasm
Biological Process:	• DNA replication • asparaginyl-tRNA aminoacylation • aspartyl-tRNA aminoacylation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004539 (mRNA)
NP_004530 (protein)

NM_027350 (mRNA)
NP_081626 (protein)

Location

Chr 18: 53.42 - 53.44 Mb

Chr 18: 64.63 - 64.64 Mb

Pubmed search

[1]

[2]

Asparaginyl-tRNA synthetase, also known as NARS, is a human gene.^[1]

Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. Asparaginyl-tRNA synthetase is localized to the cytoplasm and belongs to the class II family of tRNA synthetases. The N-terminal domain represents the signature sequence for the eukaryotic asparaginyl-tRNA synthetases.^[1]

[edit] References

^ ^a ^b Entrez Gene: NARS asparaginyl-tRNA synthetase.

[edit] Further reading

Cirullo RE, Arredondo-Vega FX, Smith M, Wasmuth JJ (1983). "Isolation and characterization of interspecific heat-resistant hybrids between a temperature-sensitive chinese hamster cell asparaginyl-tRNA synthetase mutant and normal human leukocytes: assignment of human asnS gene to chromosome 18.". Somatic Cell Genet. 9 (2): 215-33. PMID 6836455.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.
Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107-13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353-8. PMID 9110174.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
Beaulande M, Tarbouriech N, Härtlein M (1998). "Human cytosolic asparaginyl-tRNA synthetase: cDNA sequence, functional expression in Escherichia coli and characterization as human autoantigen.". Nucleic Acids Res. 26 (2): 521-4. PMID 9421509.
Shiba K, Motegi H, Yoshida M, Noda T (1999). "Human asparaginyl-tRNA synthetase: molecular cloning and the inference of the evolutionary history of Asx-tRNA synthetase family.". Nucleic Acids Res. 26 (22): 5045-51. PMID 9801298.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation.". Genome Res. 14 (7): 1315-23. doi:10.1101/gr.2122004. PMID 15231747.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801-14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.