NAPSA

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Napsin A aspartic peptidase
Identifiers
Symbol(s) NAPSA; KAP; NAP1; NAPA; SNAPA; Kdap
External IDs OMIM: 605631 MGI: 109365 HomoloGene: 68418
Orthologs
Human Mouse
Entrez 9476 16541
Ensembl ENSG00000131400 ENSMUSG00000002204
Uniprot O96009 Q3TDT8
Refseq NM_004851 (mRNA)
NP_004842 (protein)		 NM_008437 (mRNA)
NP_032463 (protein)
Location Chr 19: 55.55 - 55.56 Mb Chr 7: 44.44 - 44.45 Mb
Pubmed search [1] [2]

Napsin A aspartic peptidase, also known as NAPSA, is a human gene.[1]

The activation peptides of aspartic proteinases plays role as inhibitors of the active site. These peptide segments, or pro-parts, are deemed important for correct folding, targeting, and control of the activation of aspartic proteinase zymogens. The pronapsin A gene is expressed predominantly in lung and kidney. Its translation product is predicted to be a fully functional, glycosylated aspartic proteinase precursor containing an RGD motif and an additional 18 residues at its C-terminus.[1]

[edit] References

  1. ^ a b Entrez Gene: NAPSA napsin A aspartic peptidase.

[edit] Further reading

  • Koelsch G, Mares M, Metcalf P, Fusek M (1994). "Multiple functions of pro-parts of aspartic proteinase zymogens.". FEBS Lett. 343 (1): 6-10. PMID 8163018. 
  • Blundell TL, Guruprasad K, Albert A, et al. (1998). "The aspartic proteinases. An historical overview.". Adv. Exp. Med. Biol. 436: 1-13. PMID 9561193. 
  • Tatnell PJ, Powell DJ, Hill J, et al. (1999). "Napsins: new human aspartic proteinases. Distinction between two closely related genes.". FEBS Lett. 441 (1): 43-8. PMID 9877162. 
  • Chuman Y, Bergman A, Ueno T, et al. (2000). "Napsin A, a member of the aspartic protease family, is abundantly expressed in normal lung and kidney tissue and is expressed in lung adenocarcinomas.". FEBS Lett. 462 (1-2): 129-34. PMID 10580105. 
  • Schauer-Vukasinovic V, Bur D, Kling D, et al. (2000). "Human napsin A: expression, immunochemical detection, and tissue localization.". FEBS Lett. 462 (1-2): 135-9. PMID 10580106. 
  • Yan R, Bienkowski MJ, Shuck ME, et al. (1999). "Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity.". Nature 402 (6761): 533-7. doi:10.1038/990107. PMID 10591213. 
  • Cook M, Bühling F, Ansorge S, et al. (2002). "Pronapsin A and B gene expression in normal and malignant human lung and mononuclear blood cells.". Biochim. Biophys. Acta 1577 (1): 10-6. PMID 12151090. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Ueno T, Linder S, Elmberger G (2004). "Aspartic proteinase napsin is a useful marker for diagnosis of primary lung adenocarcinoma.". Br. J. Cancer 88 (8): 1229-33. doi:10.1038/sj.bjc.6600879. PMID 12698189. 
  • Brasch F, Ochs M, Kahne T, et al. (2004). "Involvement of napsin A in the C- and N-terminal processing of surfactant protein B in type-II pneumocytes of the human lung.". J. Biol. Chem. 278 (49): 49006-14. doi:10.1074/jbc.M306844200. PMID 13129928. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. 
  • Innocenti M, Zucconi A, Disanza A, et al. (2004). "Abi1 is essential for the formation and activation of a WAVE2 signalling complex.". Nat. Cell Biol. 6 (4): 319-27. doi:10.1038/ncb1105. PMID 15048123. 
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