NAPG

From Wikipedia, the free encyclopedia

N-ethylmaleimide-sensitive factor attachment protein, gamma

Identifiers

NAPG; GAMMASNAP

External IDs

OMIM: 603216 MGI: 104561 HomoloGene: 2838

Gene ontology
Molecular Function:	• transporter activity • protein binding
Cellular Component:	• membrane fraction • mitochondrion • endoplasmic reticulum • Golgi apparatus
Biological Process:	• protein complex assembly • intracellular protein transport • ER to Golgi vesicle-mediated transport • intra-Golgi vesicle-mediated transport • membrane fusion • protein stabilization

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003826 (mRNA)
NP_003817 (protein)

XM_001000731 (mRNA)
XP_001000731 (protein)

Location

Chr 18: 10.52 - 10.54 Mb

Chr 18: 63.1 - 63.12 Mb

Pubmed search

[1]

[2]

N-ethylmaleimide-sensitive factor attachment protein, gamma, also known as NAPG, is a human gene.^[1]

NSF and SNAPs are general elements of the cellular membrane transport apparatus. The sequence of the predicted 312-amino acid human protein encoded by NAPG is 95% identical to that of bovine gamma-SNAP. NAPG mediates platelet exocytosis and controls the membrane fusion events of this process.^[1]

[edit] References

^ ^a ^b Entrez Gene: NAPG N-ethylmaleimide-sensitive factor attachment protein, gamma.

[edit] Further reading

Wilson DW, Whiteheart SW, Wiedmann M, et al. (1992). "A multisubunit particle implicated in membrane fusion.". J. Cell Biol. 117 (3): 531-8. PMID 1315316.
Whiteheart SW, Brunner M, Wilson DW, et al. (1992). "Soluble N-ethylmaleimide-sensitive fusion attachment proteins (SNAPs) bind to a multi-SNAP receptor complex in Golgi membranes.". J. Biol. Chem. 267 (17): 12239-43. PMID 1601890.
Whiteheart SW, Griff IC, Brunner M, et al. (1993). "SNAP family of NSF attachment proteins includes a brain-specific isoform.". Nature 362 (6418): 353-5. doi:10.1038/362353a0. PMID 8455721.
Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107-13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353-8. PMID 9110174.
Mastick CC, Falick AL (1997). "Association of N-ethylmaleimide sensitive fusion (NSF) protein and soluble NSF attachment proteins-alpha and -gamma with glucose transporter-4-containing vesicles in primary rat adipocytes.". Endocrinology 138 (6): 2391-7. PMID 9165027.
Lemons PP, Chen D, Bernstein AM, et al. (1997). "Regulated secretion in platelets: identification of elements of the platelet exocytosis machinery.". Blood 90 (4): 1490-500. PMID 9269766.
Subramaniam VN, Loh E, Horstmann H, et al. (2000). "Preferential association of syntaxin 8 with the early endosome.". J. Cell. Sci. 113 ( Pt 6): 997-1008. PMID 10683148.
Chen D, Xu W, He P, et al. (2001). "Gaf-1, a gamma -SNAP-binding protein associated with the mitochondria.". J. Biol. Chem. 276 (16): 13127-35. doi:10.1074/jbc.M009424200. PMID 11278501.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Tani K, Shibata M, Kawase K, et al. (2003). "Mapping of functional domains of gamma-SNAP.". J. Biol. Chem. 278 (15): 13531-8. doi:10.1074/jbc.M213205200. PMID 12554740.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.". Nat. Biotechnol. 23 (1): 94-101. doi:10.1038/nbt1046. PMID 15592455.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.