NAP1L4

From Wikipedia, the free encyclopedia

Nucleosome assembly protein 1-like 4

Identifiers

NAP1L4; MGC4565; NAP2; NAP2L; hNAP2

External IDs

OMIM: 601651 MGI: 1316687 HomoloGene: 21209

Gene ontology
Molecular Function:	• unfolded protein binding
Cellular Component:	• nucleus • chromatin assembly complex • cytoplasm
Biological Process:	• nucleosome assembly

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005969 (mRNA)
NP_005960 (protein)

NM_008672 (mRNA)
NP_032698 (protein)

Location

Chr 11: 2.92 - 2.97 Mb

Chr 7: 143.32 - 143.35 Mb

Pubmed search

[1]

[2]

Nucleosome assembly protein 1-like 4, also known as NAP1L4, is a human gene.^[1]

This gene encodes a member of the nucleosome assembly protein (NAP) family which can interact with both core and linker histones. It can shuttle between the cytoplasm and nucleus, suggesting a role as a histone chaperone. This gene is one of several located near the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer.^[1]

[edit] References

^ ^a ^b Entrez Gene: NAP1L4 nucleosome assembly protein 1-like 4.

[edit] Further reading

Hu RJ, Lee MP, Johnson LA, Feinberg AP (1997). "A novel human homologue of yeast nucleosome assembly protein, 65 kb centromeric to the p57KIP2 gene, is biallelically expressed in fetal and adult tissues.". Hum. Mol. Genet. 5 (11): 1743–8. PMID 8923002.
Rodriguez P, Munroe D, Prawitt D, et al. (1997). "Functional characterization of human nucleosome assembly protein-2 (NAP1L4) suggests a role as a histone chaperone.". Genomics 44 (3): 253–65. doi:10.1006/geno.1997.4868. PMID 9325046.
Rodriguez P, Pelletier J, Price GB, Zannis-Hadjopoulos M (2000). "NAP-2: histone chaperone function and phosphorylation state through the cell cycle.". J. Mol. Biol. 298 (2): 225–38. doi:10.1006/jmbi.2000.3674. PMID 10764593.
Shikama N, Chan HM, Krstic-Demonacos M, et al. (2000). "Functional interaction between nucleosome assembly proteins and p300/CREB-binding protein family coactivators.". Mol. Cell. Biol. 20 (23): 8933–43. PMID 11073993.
Cicala C, Arthos J, Selig SM, et al. (2002). "HIV envelope induces a cascade of cell signals in non-proliferating target cells that favor virus replication.". Proc. Natl. Acad. Sci. U.S.A. 99 (14): 9380–5. doi:10.1073/pnas.142287999. PMID 12089333.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Rodriguez P, Ruiz MT, Price GB, Zannis-Hadjopoulos M (2005). "NAP-2 is part of multi-protein complexes in HeLa cells.". J. Cell. Biochem. 93 (2): 398–408. doi:10.1002/jcb.20163. PMID 15368365.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle.". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMID 16565220.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.