NAP1L1

From Wikipedia, the free encyclopedia

Nucleosome assembly protein 1-like 1

Identifiers

NAP1L1; NAP1; FLJ16112; MGC23410; MGC8688; NAP1L; NRP

External IDs

OMIM: 164060 MGI: 1855693 HomoloGene: 4355

Gene ontology
Molecular Function:	• protein binding
Cellular Component:	• nucleus • chromatin assembly complex
Biological Process:	• DNA replication • nucleosome assembly • positive regulation of cell proliferation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004537 (mRNA)
NP_004528 (protein)

NM_015781 (mRNA)
NP_056596 (protein)

Location

Chr 12: 74.73 - 74.76 Mb

Chr 10: 110.88 - 110.9 Mb

Pubmed search

[1]

[2]

Nucleosome assembly protein 1-like 1, also known as NAP1L1, is a human gene.^[1]

This gene encodes a member of the nucleosome assembly protein (NAP) family. This protein participates in DNA replication and may play a role in modulating chromatin formation and contribute to the regulation of cell proliferation. Alternative splicing of this gene results in several transcript variants; however, not all have been fully described.^[1]

[edit] References

^ ^a ^b Entrez Gene: NAP1L1 nucleosome assembly protein 1-like 1.

[edit] Further reading

Kato S, Sekine S, Oh SW, et al. (1995). "Construction of a human full-length cDNA bank.". Gene 150 (2): 243-50. PMID 7821789.
Simon HU, Mills GB, Kozlowski M, et al. (1994). "Molecular characterization of hNRP, a cDNA encoding a human nucleosome-assembly-protein-I-related gene product involved in the induction of cell proliferation.". Biochem. J. 297 ( Pt 2): 389-97. PMID 8297347.
Asahara H, Tartare-Deckert S, Nakagawa T, et al. (2002). "Dual roles of p300 in chromatin assembly and transcriptional activation in cooperation with nucleosome assembly protein 1 in vitro.". Mol. Cell. Biol. 22 (9): 2974-83. PMID 11940655.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.". Nat. Cell Biol. 6 (2): 97-105. doi:10.1038/ncb1086. PMID 14743216.
Rehtanz M, Schmidt HM, Warthorst U, Steger G (2004). "Direct interaction between nucleosome assembly protein 1 and the papillomavirus E2 proteins involved in activation of transcription.". Mol. Cell. Biol. 24 (5): 2153-68. PMID 14966293.
Kho Y, Kim SC, Jiang C, et al. (2004). "A tagging-via-substrate technology for detection and proteomics of farnesylated proteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (34): 12479-84. doi:10.1073/pnas.0403413101. PMID 15308774.
Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain.". Mol. Cell Proteomics 3 (11): 1093-101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Okuwaki M, Kato K, Shimahara H, et al. (2005). "Assembly and disassembly of nucleosome core particles containing histone variants by human nucleosome assembly protein I.". Mol. Cell. Biol. 25 (23): 10639-51. doi:10.1128/MCB.25.23.10639-10651.2005. PMID 16287874.
Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle.". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391-6. doi:10.1073/pnas.0507066103. PMID 16565220.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285-92. doi:10.1038/nbt1240. PMID 16964243.
Chi A, Valencia JC, Hu ZZ, et al. (2007). "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.". J. Proteome Res. 5 (11): 3135-44. doi:10.1021/pr060363j. PMID 17081065.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635-48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Eckey M, Hong W, Papaioannou M, Baniahmad A (2007). "The nucleosome assembly activity of NAP1 is enhanced by Alien.". Mol. Cell. Biol. 27 (10): 3557-68. doi:10.1128/MCB.01106-06. PMID 17339334.