NADPH dehydrogenase (quinone)
From Wikipedia, the free encyclopedia
In enzymology, a NADPH dehydrogenase (quinone) (EC 1.6.99.6) is an enzyme that catalyzes the chemical reaction
- NADPH + H+ + acceptor
NADP+ + reduced acceptor
The 3 substrates of this enzyme are NADPH, H+, and acceptor, whereas its two products are NADP+ and reduced acceptor.
This enzyme belongs to the family of oxidoreductases, specifically those acting on NADH or NADPH with other acceptors. The systematic name of this enzyme class is NADPH:(quinone-acceptor) oxidoreductase. Other names in common use include reduced nicotinamide adenine dinucleotide phosphate (quinone), dehydrogenase, NADPH oxidase, and NADPH2 dehydrogenase (quinone). It has 2 cofactors: FAD, and Flavoprotein. Several compounds are known to inhibit this enzyme, including Folate, and Dicumarol.
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[edit] Structural studies
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1F5V.
[edit] References
- IUBMB entry for 1.6.99.6
- BRENDA references for 1.6.99.6 (Recommended.)
- PubMed references for 1.6.99.6
- PubMed Central references for 1.6.99.6
- Google Scholar references for 1.6.99.6
- Koli AK, Yearby C, Scott W, Donaldson KO (1969). "Purification and properties of three separate menadione reductases from hog liver". J. Biol. Chem. 244: 621–9. PMID 4388793.
[edit] External links
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- The CAS registry number for this enzyme class is 37256-37-4.
[edit] Gene Ontology (GO) codes
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