NAD+ synthase

From Wikipedia, the free encyclopedia

In enzymology, a NAD+ synthase (EC 6.3.1.5) is an enzyme that catalyzes the chemical reaction

ATP + deamido-NAD⁺ + NH₃ AMP + diphosphate + NAD⁺

The 3 substrates of this enzyme are ATP, deamido-NAD+, and NH₃, whereas its 3 products are AMP, diphosphate, and NAD⁺.

This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds as acid-D-ammonia (or amine) ligases (amide synthases). The systematic name of this enzyme class is deamido-NAD+:ammonia ligase (AMP-forming). Other names in common use include NAD+ synthetase, NAD+ synthase, nicotinamide adenine dinucleotide synthetase, and diphosphopyridine nucleotide synthetase. This enzyme participates in nicotinate and nicotinamide metabolism and nitrogen metabolism.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 11 structures have been solved for this class of enzymes, with PDB accession codes 1WXE, 1WXF, 1WXG, 1WXH, 1WXI, 1XNG, 1XNH, 2E18, 2PZ8, 2PZA, and 2PZB.

[edit] References

• IUBMB entry for 6.3.1.5
• BRENDA references for 6.3.1.5 (Recommended.)
• PubMed references for 6.3.1.5
• PubMed Central references for 6.3.1.5
• Google Scholar references for 6.3.1.5
• Spencer RL, Preiss J (1967). "Biosynthesis of diphosphopyridine nucleotide. The purification and the properties of diphospyridine nucleotide synthetase from Escherichia coli b". J. Biol. Chem. 242: 385–92. PMID 4290215. 

[edit] External links

The CAS registry number for this enzyme class is 9032-69-3.

• IUBMB entry for 6.3.1.5

• KEGG entry for 6.3.1.5

• BRENDA entry for 6.3.1.5

• NiceZyme view of 6.3.1.5

• EC2PDB: PDB structures for 6.3.1.5

• PRIAM entry for 6.3.1.5

• PUMA2 entry for 6.3.1.5

• IntEnz: Integrated Enzyme entry for 6.3.1.5

• MetaCyc entry for 6.3.1.5

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0008795: NAD+ synthase

• AMIGO entry for GO code 0008795: NAD+ synthase