NAD+ kinase

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Ribbon diagram of NAD+ kinase in complex with substrates.
NAD+ kinase
Identifiers
Symbol NADK
Entrez 65220
HUGO 29831
PDB 1SUW
RefSeq NP_075394.3
UniProt O95544
Other data
EC number 2.7.1.23
Locus Chr. 1 p1p36.33

NAD+ kinase (EC 2.7.1.23, NADK) is an enzyme that converts nicotinamide adenine dinucleotide (NAD+) into NADP+, through phosphorylating the NAD+ coenzyme.[1] NADP+ is an essential coenzyme in metabolism and provides reducing power to biosynthetic processes such as fatty acid biosynthesis.[2] The structure of the NADK from the archaean Archaeoglobus fulgidus has been determined.[3]

Reaction

ATP + NAD(+) <=> ADP + NADP(+)

[edit] See also

[edit] References

  1. ^ Magni G, Orsomando G, Raffaelli N (2006). "Structural and functional properties of NAD kinase, a key enzyme in NADP biosynthesis". Mini reviews in medicinal chemistry 6 (7): 739–46. doi:10.2174/138955706777698688. PMID 16842123. 
  2. ^ Pollak N, Dölle C, Ziegler M (2007). "The power to reduce: pyridine nucleotides--small molecules with a multitude of functions". Biochem. J. 402 (2): 205–18. doi:10.1042/BJ20061638. PMID 17295611. 
  3. ^ Liu J, Lou Y, Yokota H, Adams PD, Kim R, Kim SH (2005). "Crystal structures of an NAD kinase from Archaeoglobus fulgidus in complex with ATP, NAD, or NADP". J. Mol. Biol. 354 (2): 289–303. doi:10.1016/j.jmb.2005.09.026. PMID 16242716. 

[edit] External links