NAD+ diphosphatase

From Wikipedia, the free encyclopedia

In enzymology, a NAD+ diphosphatase (EC 3.6.1.22) is an enzyme that catalyzes the chemical reaction

NAD⁺ + H₂O AMP + NMN

Thus, the two substrates of this enzyme are NAD⁺ and H₂O, whereas its two products are AMP and NMN.

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing anhydrides. The systematic name of this enzyme class is NAD+ phosphohydrolase. Other names in common use include nicotinamide adenine dinucleotide pyrophosphatase, NADP+ pyrophosphatase, and NADH pyrophosphatase. This enzyme participates in nicotinate and nicotinamide metabolism.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2GB5.

[edit] References

• IUBMB entry for 3.6.1.22
• BRENDA references for 3.6.1.22 (Recommended.)
• PubMed references for 3.6.1.22
• PubMed Central references for 3.6.1.22
• Google Scholar references for 3.6.1.22
• Anderson BM, Lang CA (1966). "Nicotinamide-adenine dinucleotide pyrophosphatase in the growing and aging mosquito". Biochem. J. 101: 392–6. PMID 4381708. 
• Nakajima Y, Fukunaga N, Sasaki S, Usami S (1973). "Purification and properties of NADP pyrophosphatase from Proteus vulgaris". Biochim. Biophys. Acta. 293: 242–55. PMID 4405504. 

[edit] External links

The CAS registry number for this enzyme class is 37289-33-1.

• IUBMB entry for 3.6.1.22

• KEGG entry for 3.6.1.22

• BRENDA entry for 3.6.1.22

• NiceZyme view of 3.6.1.22

• EC2PDB: PDB structures for 3.6.1.22

• PRIAM entry for 3.6.1.22

• PUMA2 entry for 3.6.1.22

• IntEnz: Integrated Enzyme entry for 3.6.1.22

• MetaCyc entry for 3.6.1.22

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0000210: NAD+ diphosphatase

• AMIGO entry for GO code 0000210: NAD+ diphosphatase