NAD+-diphthamide ADP-ribosyltransferase
From Wikipedia, the free encyclopedia
In enzymology, a NAD+-diphthamide ADP-ribosyltransferase (EC 2.4.2.36) is an enzyme that catalyzes the chemical reaction
- NAD+ + peptide diphthamide
nicotinamide + peptide N-(ADP-D-ribosyl)diphthamide
Thus, the two substrates of this enzyme are NAD+ and peptide diphthamide, whereas its two products are nicotinamide and peptide N-(ADP-D-ribosyl)diphthamide.
This enzyme belongs to the family of glycosyltransferases, specifically the pentosyltransferases. The systematic name of this enzyme class is NAD+:peptide-diphthamide N-(ADP-D-ribosyl)transferase. Other names in common use include ADP-ribosyltransferase, mono(ADPribosyl)transferase, and NAD-diphthamide ADP-ribosyltransferase.
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[edit] Structural studies
As of late 2007, 15 structures have been solved for this class of enzymes, with PDB accession codes 1S5B, 1S5C, 1S5D, 1S5E, 1S5F, 1SGK, 1TOX, 1XDT, 1XK9, 1ZM3, 1ZM4, 1ZM9, 2A5D, 2A5F, and 2A5G.
[edit] References
- IUBMB entry for 2.4.2.36
- BRENDA references for 2.4.2.36 (Recommended.)
- PubMed references for 2.4.2.36
- PubMed Central references for 2.4.2.36
- Google Scholar references for 2.4.2.36
- Lee H, Iglewski WJ (1984). "Cellular ADP-ribosyltransferase with the same mechanism of action as diphtheria toxin and Pseudomonas toxin A". Proc. Natl. Acad. Sci. U. S. A. 81: 2703–7. doi:. PMID 6326138.
- Ueda K, Hayaishi O (1985). "ADP-ribosylation". Annu. Rev. Biochem. 54: 73–100. doi:. PMID 3927821.
[edit] External links
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- The CAS registry number for this enzyme class is 52933-21-8.
[edit] Gene Ontology (GO) codes
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