NAD(P)+ transhydrogenase (B-specific)

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In enzymology, a NAD(P)+ transhydrogenase (B-specific) (EC 1.6.1.1) is an enzyme that catalyzes the chemical reaction

NADPH + NAD⁺ $\rightleftharpoons$ NADP⁺ + NADH

Thus, the two substrates of this enzyme are NADPH and NAD⁺, whereas its two products are NADP⁺ and NADH.

This enzyme belongs to the family of oxidoreductases, specifically those acting on NADH or NADPH with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is NADPH:NAD+ oxidoreductase (B-specific). Other names in common use include pyridine nucleotide transhydrogenase, transhydrogenase, NAD(P)+ transhydrogenase, nicotinamide adenine dinucleotide (phosphate) transhydrogenase, NAD+ transhydrogenase, NADH transhydrogenase, nicotinamide nucleotide transhydrogenase, NADPH-NAD+ transhydrogenase, pyridine nucleotide transferase, NADPH-NAD+ oxidoreductase, NADH-NADP+-transhydrogenase, NADPH:NAD+ transhydrogenase, H+-Thase, non-energy-linked transhydrogenase, and NAD(P)+ transhydrogenase (B-specific). This enzyme participates in nicotinate and nicotinamide metabolism. It employs one cofactor, FAD.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes 1D4O, 1DJL, 1E3T, 1F8G, 1HZZ, 1L7D, and 1L7E.

[edit] References

IUBMB entry for 1.6.1.1
BRENDA references for 1.6.1.1 (Recommended.)
PubMed references for 1.6.1.1
PubMed Central references for 1.6.1.1
Google Scholar references for 1.6.1.1
HUMPHREY GF (1957). "The distribution and properties of transhydrogenase from animal tissues". Biochem. J. 65: 546–50. PMID 13412660.
You KS (1985). "Stereospecificity for nicotinamide nucleotides in enzymatic and chemical hydride transfer reactions". CRC. Crit. Rev. Biochem. 17: 313–451. doi:10.3109/10409238509113625. PMID 3157549.