NACA (gene)

From Wikipedia, the free encyclopedia

Nascent-polypeptide-associated complex alpha polypeptide

Identifiers

NACA; HSD48; MGC117224

External IDs

OMIM: 601234 MGI: 106095 HomoloGene: 55914

Gene ontology
Molecular Function:	• DNA binding
Cellular Component:	• nucleus • cytoplasm • nascent polypeptide-associated complex
Biological Process:	• transcription • translation • protein transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005594 (mRNA)
NP_005585 (protein)

NM_013608 (mRNA)
NP_038636 (protein)

Location

Chr 12: 55.39 - 55.41 Mb

Chr 10: 127.44 - 127.45 Mb

Pubmed search

[1]

[2]

Nascent-polypeptide-associated complex alpha polypeptide, also known as NACA, is a human gene.^[1]

[edit] References

^ Entrez Gene: NACA nascent-polypeptide-associated complex alpha polypeptide.

[edit] Further reading

Wiedmann B, Sakai H, Davis TA, Wiedmann M (1994). "A protein complex required for signal-sequence-specific sorting and translocation.". Nature 370 (6489): 434–40. doi:10.1038/370434a0. PMID 8047162.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Yotov WV, St-Arnaud R (1996). "Mapping of the human gene for the alpha-NAC/1.9.2 (NACA/1.9.2) transcriptional coactivator to Chromosome 12q23-24.1.". Mamm. Genome 7 (2): 163–4. PMID 8835540.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Yotov WV, Moreau A, St-Arnaud R (1998). "The alpha chain of the nascent polypeptide-associated complex functions as a transcriptional coactivator.". Mol. Cell. Biol. 18 (3): 1303–11. PMID 9488445.
Moreau A, Yotov WV, Glorieux FH, St-Arnaud R (1998). "Bone-specific expression of the alpha chain of the nascent polypeptide-associated complex, a coactivator potentiating c-Jun-mediated transcription.". Mol. Cell. Biol. 18 (3): 1312–21. PMID 9488446.
Munz B, Wiedmann M, Lochmüller H, Werner S (1999). "Cloning of novel injury-regulated genes. Implications for an important role of the muscle-specific protein skNAC in muscle repair.". J. Biol. Chem. 274 (19): 13305–10. PMID 10224091.
Beatrix B, Sakai H, Wiedmann M (2001). "The alpha and beta subunit of the nascent polypeptide-associated complex have distinct functions.". J. Biol. Chem. 275 (48): 37838–45. doi:10.1074/jbc.M006368200. PMID 10982809.
Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.". Genome Res. 10 (10): 1546–60. PMID 11042152.
Sims RJ, Weihe EK, Zhu L, et al. (2002). "m-Bop, a repressor protein essential for cardiogenesis, interacts with skNAC, a heart- and muscle-specific transcription factor.". J. Biol. Chem. 277 (29): 26524–9. doi:10.1074/jbc.M204121200. PMID 12011100.
Kim SH, Shim KS, Lubec G (2002). "Human brain nascent polypeptide-associated complex alpha subunit is decreased in patients with Alzheimer' s disease and Down syndrome.". J. Investig. Med. 50 (4): 293–301. PMID 12109594.
Behrends U, Jandl T, Golbeck A, et al. (2002). "Novel products of the HUD, HUC, NNP-1 and alpha-internexin genes identified by autologous antibody screening of a pediatric neuroblastoma library.". Int. J. Cancer 100 (6): 669–77. doi:10.1002/ijc.10550. PMID 12209604.
Mossabeb R, Seiberler S, Mittermann I, et al. (2002). "Characterization of a novel isoform of alpha-nascent polypeptide-associated complex as IgE-defined autoantigen.". J. Invest. Dermatol. 119 (4): 820–9. doi:10.1046/j.1523-1747.2002.00518.x. PMID 12406326.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Stilo R, Liguoro D, di Jeso B, et al. (2003). "The alpha-chain of the nascent polypeptide-associated complex binds to and regulates FADD function.". Biochem. Biophys. Res. Commun. 303 (4): 1034–41. PMID 12684039.
Papachristou DJ, Batistatou A, Sykiotis GP, et al. (2003). "Activation of the JNK-AP-1 signal transduction pathway is associated with pathogenesis and progression of human osteosarcomas.". Bone 32 (4): 364–71. PMID 12689679.
Hämmerle K, Shayan P, Niemeyer CM, Flotho C (2003). "Expression analysis of alpha-NAC and ANX2 in juvenile myelomonocytic leukemia using SMART polymerase chain reaction and "virtual Northern" hybridization.". Cancer Genet. Cytogenet. 142 (2): 149–52. PMID 12699894.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Al-Shanti N, Steward CG, Garland RJ, Rowbottom AW (2004). "Investigation of alpha nascent polypeptide-associated complex functions in a human CD8(+) T cell ex vivo expansion model using antisense oligonucleotides.". Immunology 112 (3): 397–403. doi:10.1111/j.1365-2567.2004.01893.x. PMID 15196207.
Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain.". Mol. Cell Proteomics 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.