Talk:Na+/K+-ATPase

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Contents 1 Pharmacology 2 Nomenclature 3 Name 4 Nursing Implications of Sodium Potassium Pump 5 Working in reverse? 6 Remove exclamation mark in "Function - Mechanism" 7 Why an enzyme 8 Critisism to Na+/K+-ATPase

[edit] Pharmacology

Could someone please rework the pharmacology section so that the role of Na/K ATPase in Ca²⁺ sequestration is more clear?

[edit] Nomenclature

Is sodium pump not a more generally used name??

You could add mention of sodium pump to the article. It gets 1886 hits on this search engine. There should probably be an entire section of the article that describes the various versions of the name. They list six here. —Preceding unsigned comment added by 84.51.156.172 (talk • contribs) . Signed by Brazucs

Please add ~~~~~ to the end of your comments on discussion pages. --JWSchmidt 13:20, 14 December 2005 (UTC)

I have always seen it written as sodium-potassium pump. --Brazucs (_TALK | ^CONTRIBS) 05:08, 19 April 2006 (UTC)

there are a class of sodium-specific channels essential for membrane depolarization, and the pump/channel could be confusing. Sovbeos 14:05, 25 September 2007 (UTC)

[edit] Name

I find the plus signs in the title of this article distracting. I propose we instead use the much cleaner "Na,K-ATPase", which is used in several physiology textbooks, notably Boron and Boulpaep's Medical Physiology. Thoughts? --David Iberri (talk) 21:47, 20 May 2006 (UTC)

I agree Sovbeos 14:05, 25 September 2007 (UTC)

[edit] Nursing Implications of Sodium Potassium Pump

Requesting fluid and electrolyte, and IV implications of the sodium potassium pump mechanism. This seems like a lot of information with no practical application, and is therefore difficult to conceptualize. 76.19.146.152 23:36, 6 March 2007 (UTC)ASB

[edit] Working in reverse?

According to my Cellular Biology textbook (ISBN 0815332181) the sodium-potassium ATPase can also work in reverse. Under a high K⁺/Na⁺ electro-chemical gradient and depending on the concentrations of ADP and ATP inside the cell, the enzyme can phosphorylize ADP by transporting Na⁺ into the cell and K⁺ out of the cell. Seems to be an equilibrium sort of thing. If anyone can confirm, please add it to the article. Aurimas 05:26, 19 September 2007 (UTC)

[edit] Remove exclamation mark in "Function - Mechanism"

It's a serious article, and the fact that the reaction repeats itself again does not mean it is funny, or requires an exclamation mark —Preceding unsigned comment added by 194.81.255.254 (talk) 17:17, 14 October 2007 (UTC)

[edit] Why an enzyme

The definition that I have always been told, which now seems to be wrong, is that an enzyme is biological catalyst, speeding up reactions, is this definition incomplete because this doesn't seem to be changing a reaction speed. —Preceding unsigned comment added by Murdochious (talk • contribs) 21:27, 5 November 2007 (UTC)

[edit] Critisism to Na+/K+-ATPase

I added a section about the critisism of the Na+/K+-ATPase. It was reverted by User:JWSchmidt http://en.wikipedia.org/w/index.php?title=Na%2B/K%2B-ATPase&oldid=184179079 I admit that I don't have the capability to see if it's a fringe website, but it seems to me that it should be mentioned in the article, because this specific theory has been widespread in the media (UTFG); even more then if someone here could provide a link which gives a counterview to the theories of Gilbert Ling, which may eventually expose them as a fringe science. --84.226.130.70 (talk) 03:58, 14 January 2008 (UTC)

Please suggest one or more specific peer-reviewed publications which gives a critical view of the Na+/K+-ATPase.....we can start from there. A personal website is not a good source to cite. --JWSchmidt (talk) 04:07, 14 January 2008 (UTC)

That's true indeed. I took a look at the 3 disprovals which Ling lists on his website [1]. (1) is a overview of different research papers (done by Ling himself) published by Blaisdell Pub. Co (2) is an article by Mullins and Brinley published in The Journal of General Physiology (3) is an article (again by Ling himself) published in The Journal of Physiology. Again I have to admit that I'm not familiar with this specific scientific community. I assume that (2) and (3) were peer reviewed, while (3) is more likely to criticise the Na+/K+-ATPase as it is from Ling himself. However the abstract of (3) does not itself directly mentions a disproval. --84.226.130.70 (talk) 05:57, 14 January 2008 (UTC)

In (3), Ling seems particularly concerned with promoting the idea that in living cells, "anionic sites of certain protoplasmic proteins.....have more favourable adsorption energies for K⁺ than for Na⁺." He proposed that this selectivity for K⁺ binding to cellular proteins depends on ATP. "When ATP is removed during cell deterioration, the system goes into an alternative co-operative state, in which selectivity for K⁺ adsorption is lost". There is a rather extensive literature on ATP-binding proteins...are there any good publications that describe proteins shifting their K⁺-binding affinity in an ATP-depedent way? --JWSchmidt (talk) 22:59, 14 January 2008 (UTC)