N6-acetyl-beta-lysine transaminase

From Wikipedia, the free encyclopedia

In enzymology, a N6-acetyl-beta-lysine transaminase (EC 2.6.1.65) is an enzyme that catalyzes the chemical reaction

6-acetamido-3-aminohexanoate + 2-oxoglutarate $\rightleftharpoons$ 6-acetamido-3-oxohexanoate + L-glutamate

Thus, the two substrates of this enzyme are 6-acetamido-3-aminohexanoate and 2-oxoglutarate, whereas its two products are 6-acetamido-3-oxohexanoate and L-glutamate.

This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. The systematic name of this enzyme class is 6-acetamido-3-aminohexanoate:2-oxoglutarate aminotransferase. This enzyme is also called epsilon-acetyl-beta-lysine aminotransferase. This enzyme participates in lysine degradation. It employs one cofactor, pyridoxal phosphate.

[edit] References

IUBMB entry for 2.6.1.65
BRENDA references for 2.6.1.65 (Recommended.)
PubMed references for 2.6.1.65
PubMed Central references for 2.6.1.65
Google Scholar references for 2.6.1.65
Bozler G, Robertson JM, Ohsugi M, Hensley C, Barker HA (1979). "Metabolism of L-beta-lysine in a Pseudomonas: conversion of 6-N-acetyl-L-beta-lysine to 3-keto-6-acetamidohexanoate and of 4-aminobutyrate to succinic semialdehyde by different transaminases". Arch. Biochem. Biophys. 197: 226–35. doi:10.1016/0003-9861(79)90240-6. PMID 44448.