N5-(carboxyethyl)ornithine synthase

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In enzymology, a N5-(carboxyethyl)ornithine synthase (EC 1.5.1.24) is an enzyme that catalyzes the chemical reaction

N₅-(L-1-carboxyethyl)-L-ornithine + NADP⁺ + H₂O L-ornithine + pyruvate + NADPH + H⁺

The 3 substrates of this enzyme are N5-(L-1-carboxyethyl)-L-ornithine, NADP⁺, and H₂O, whereas its 4 products are L-ornithine, pyruvate, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is N5-(L-1-carboxyethyl)-L-ornithine:NADP+ oxidoreductase (L-ornithine-forming). Other names in common use include 5-N-(L-1-carboxyethyl)-L-ornithine:NADP+ oxidoreductase, and (L-ornithine-forming).

[edit] References

• IUBMB entry for 1.5.1.24
• BRENDA references for 1.5.1.24 (Recommended.)
• PubMed references for 1.5.1.24
• PubMed Central references for 1.5.1.24
• Google Scholar references for 1.5.1.24
• Thompson J (1989). "N5-(L-1-carboxyethyl)-L-ornithine:NADP+ oxidoreductase from Streptococcus lactis. Purification and partial characterization". J. Biol. Chem. 264: 9592–601. PMID 2498334. 

[edit] External links

The CAS registry number for this enzyme class is 129070-70-8.

• IUBMB entry for 1.5.1.24

• KEGG entry for 1.5.1.24

• BRENDA entry for 1.5.1.24

• NiceZyme view of 1.5.1.24

• EC2PDB: PDB structures for 1.5.1.24

• PRIAM entry for 1.5.1.24

• PUMA2 entry for 1.5.1.24

• IntEnz: Integrated Enzyme entry for 1.5.1.24

• MetaCyc entry for 1.5.1.24

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047126: N5-(carboxyethyl)ornithine synthase

• AMIGO entry for GO code 0047126: N5-(carboxyethyl)ornithine synthase