N-sulfoglucosamine-3-sulfatase

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In enzymology, a N-sulfoglucosamine-3-sulfatase (EC 3.1.6.15) is an enzyme that catalyzes the chemical reaction of cleaving off the 3-sulfate groups of the N-sulfo-D-glucosamine 3-O-sulfate units of heparin.

This enzyme belongs to the family of hydrolases, specifically those acting on sulfuric ester bonds. The systematic name of this enzyme class is N-sulfo-3-sulfoglucosamine 3-sulfohydrolase. This enzyme is also called chondroitinsulfatase. This enzyme participates in the degradtaion of glycan structures.

[edit] References

• IUBMB entry for 3.1.6.15
• BRENDA references for 3.1.6.15 (Recommended.)
• PubMed references for 3.1.6.15
• PubMed Central references for 3.1.6.15
• Google Scholar references for 3.1.6.15
• Bruce JS, McLean MW, Long WF, Williamson FB (1985). "Flavobacterium heparinum 3-O-sulphatase for N-substituted glucosamine 3-O-sulphate". Eur. J. Biochem. 148: 359–65. PMID 3987694. 
• Leder IG (1980). "A novel 3-O sulfatase from human urine acting on methyl-2-deoxy-2-sulfamino-alphs-D-glucopyranoside 3-sulfate". Biochem. Biophys. Res. Commun. 94: 1183–9. PMID 7396957. 

[edit] External links

• IUBMB entry for 3.1.6.15

• KEGG entry for 3.1.6.15

• BRENDA entry for 3.1.6.15

• NiceZyme view of 3.1.6.15

• EC2PDB: PDB structures for 3.1.6.15

• PRIAM entry for 3.1.6.15

• PUMA2 entry for 3.1.6.15

• IntEnz: Integrated Enzyme entry for 3.1.6.15

• MetaCyc entry for 3.1.6.15

• Atomic-resolution structures of enzymes belonging to this class