N-methylhydantoinase (ATP-hydrolysing)

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In enzymology, a N-methylhydantoinase (ATP-hydrolysing) (EC 3.5.2.14) is an enzyme that catalyzes the chemical reaction

ATP + N-methylimidazolidine-2,4-dione + 2 H₂O ADP + phosphate + N-carbamoylsarcosine

The 3 substrates of this enzyme are ATP, N-methylimidazolidine-2,4-dione, and H₂O, whereas its 3 products are ADP, phosphate, and N-carbamoylsarcosine.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amides. The systematic name of this enzyme class is N-methylimidazolidine-2,4-dione amidohydrolase (ATP-hydrolysing). Other names in common use include N-methylhydantoin amidohydrolase, methylhydantoin amidase, N-methylhydantoin hydrolase, and N-methylhydantoinase. This enzyme participates in arginine and proline metabolism.

[edit] References

• IUBMB entry for 3.5.2.14
• BRENDA references for 3.5.2.14 (Recommended.)
• PubMed references for 3.5.2.14
• PubMed Central references for 3.5.2.14
• Google Scholar references for 3.5.2.14
• Kim JM, Shimizu S, Yamada H (1987). "Amidohydrolysis of N-methylhydantoin coupled with ATP hydrolysis". Biochem. Biophys. Res. Commun. 142: 1006–12. doi:10.1016/0006-291X(87)91514-2. PMID 3827889. 

[edit] External links

The CAS registry number for this enzyme class is 100785-00-0.

• IUBMB entry for 3.5.2.14

• KEGG entry for 3.5.2.14

• BRENDA entry for 3.5.2.14

• NiceZyme view of 3.5.2.14

• EC2PDB: PDB structures for 3.5.2.14

• PRIAM entry for 3.5.2.14

• PUMA2 entry for 3.5.2.14

• IntEnz: Integrated Enzyme entry for 3.5.2.14

• MetaCyc entry for 3.5.2.14

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047423: N-methylhydantoinase (ATP-hydrolyzing)

• AMIGO entry for GO code 0047423: N-methylhydantoinase (ATP-hydrolyzing)