N-methylalanine dehydrogenase

From Wikipedia, the free encyclopedia

In enzymology, a N-methylalanine dehydrogenase (EC 1.4.1.17) is an enzyme that catalyzes the chemical reaction

N-methyl-L-alanine + H₂O + NADP⁺ pyruvate + methylamine + NADPH + H⁺

The 3 substrates of this enzyme are N-methyl-L-alanine, H₂O, and NADP⁺, whereas its 4 products are pyruvate, methylamine, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH2 group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is N-methyl-L-alanine:NADP+ oxidoreductase (demethylating, deaminating).

[edit] References

• IUBMB entry for 1.4.1.17
• BRENDA references for 1.4.1.17 (Recommended.)
• PubMed references for 1.4.1.17
• PubMed Central references for 1.4.1.17
• Google Scholar references for 1.4.1.17
• Lin MC, Wagner C (1975). "Purification and characterization of N-methylalanine dehydrogenase". J. Biol. Chem. 250: 3746–51. PMID 236301. 

[edit] External links

The CAS registry number for this enzyme class is 56379-51-2.

• IUBMB entry for 1.4.1.17

• KEGG entry for 1.4.1.17

• BRENDA entry for 1.4.1.17

• NiceZyme view of 1.4.1.17

• EC2PDB: PDB structures for 1.4.1.17

• PRIAM entry for 1.4.1.17

• PUMA2 entry for 1.4.1.17

• IntEnz: Integrated Enzyme entry for 1.4.1.17

• MetaCyc entry for 1.4.1.17

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050132: N-methylalanine dehydrogenase

• AMIGO entry for GO code 0050132: N-methylalanine dehydrogenase