N-methyl-L-amino-acid oxidase

From Wikipedia, the free encyclopedia

In enzymology, a N-methyl-L-amino-acid oxidase (EC 1.5.3.2) is an enzyme that catalyzes the chemical reaction

an N-methyl-L-amino acid + H₂O + O₂ an L-amino acid + formaldehyde + H₂O₂

The 3 substrates of this enzyme are N-methyl-L-amino acid, H₂O, and O₂, whereas its 3 products are L-amino acid, formaldehyde, and H₂O₂.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with oxygen as acceptor. The systematic name of this enzyme class is N-methyl-L-amino-acid:oxygen oxidoreductase (demethylating). Other names in common use include N-methylamino acid oxidase, and demethylase. It has 2 cofactors: FAD, and Flavoprotein.

[edit] References

• IUBMB entry for 1.5.3.2
• BRENDA references for 1.5.3.2 (Recommended.)
• PubMed references for 1.5.3.2
• PubMed Central references for 1.5.3.2
• Google Scholar references for 1.5.3.2
• Moritani M (1952). "Demethylase. IV. Kinetics and reaction mechanism". Hukuoka Acta Med. 43: 651–658. 
• Moritani M (1952). "Demethylase. V. Specificity and its relation to amino acid oxidase". Hukuoka Acta Med. 43: 731–735. 
• HIROHATA R (1954). "Specificity of rabbit kidney demethylase". J. Biol. Chem. 209: 485–92. PMID 13192101. 

[edit] External links

The CAS registry number for this enzyme class is 9029-23-6.

• IUBMB entry for 1.5.3.2

• KEGG entry for 1.5.3.2

• BRENDA entry for 1.5.3.2

• NiceZyme view of 1.5.3.2

• EC2PDB: PDB structures for 1.5.3.2

• PRIAM entry for 1.5.3.2

• PUMA2 entry for 1.5.3.2

• IntEnz: Integrated Enzyme entry for 1.5.3.2

• MetaCyc entry for 1.5.3.2

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050131: N-methyl-L-amino-acid oxidase

• AMIGO entry for GO code 0050131: N-methyl-L-amino-acid oxidase