N-hydroxy-2-acetamidofluorene reductase

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In enzymology, a N-hydroxy-2-acetamidofluorene reductase (EC 1.7.1.12) is an enzyme that catalyzes the chemical reaction

2-acetamidofluorene + NAD(P)+ + H₂O $\rightleftharpoons$ N-hydroxy-2-acetamidofluorene + NAD(P)H + H⁺

The 4 substrates of this enzyme are 2-acetamidofluorene, NAD⁺, NADP⁺, and H₂O, whereas its 4 products are N-hydroxy-2-acetamidofluorene, NADH, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on other nitrogenous compounds as donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 2-acetamidofluorene:NAD(P)+ oxidoreductase. Other names in common use include N-hydroxy-2-acetylaminofluorene reductase, and NAD(P)H:N-hydroxy-2-acetamidofluorene N-oxidoreductase.

[edit] References

IUBMB entry for 1.7.1.12
BRENDA references for 1.7.1.12 (Recommended.)
PubMed references for 1.7.1.12
PubMed Central references for 1.7.1.12
Google Scholar references for 1.7.1.12
Gutmann HR, Erickson RR (1969). "The conversion of the carcinogen N-hydroxy-2-fluorenylacetamide to o-amidophenols by rat liver in vitro. An inducible enzymatic reaction". J. Biol. Chem. 244: 1729–40. PMID 5780838.
Kitamura S, Tatsumi K (1985). "Purification of N-hydroxy-2-acetylaminofluorene reductase from rabbit liver cytosol". Biochem. Biophys. Res. Commun. 133: 67–74. doi:10.1016/0006-291X(85)91842-X. PMID 4074379.