N-formylmethionylaminoacyl-tRNA deformylase

From Wikipedia, the free encyclopedia

In enzymology, a N-formylmethionylaminoacyl-tRNA deformylase (EC 3.5.1.27) is an enzyme that catalyzes the chemical reaction

N-formyl-L-methionylaminoacyl-tRNA + H₂O formate + L-methionylaminoacyl-tRNA

Thus, the two substrates of this enzyme are N-formyl-L-methionylaminoacyl-tRNA and H₂O, whereas its two products are formate and L-methionylaminoacyl-tRNA.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is N-formyl-L-methionylaminoacyl-tRNA amidohydrolase. This enzyme participates in glyoxylate and dicarboxylate metabolism.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1BSJ, 1BSK, and 1LMH.

[edit] References

• IUBMB entry for 3.5.1.27
• BRENDA references for 3.5.1.27 (Recommended.)
• PubMed references for 3.5.1.27
• PubMed Central references for 3.5.1.27
• Google Scholar references for 3.5.1.27
• Livingston DM, Leder P (1969). "Deformylation and protein biosynthesis". Biochemistry. 8: 435–43. doi:10.1021/bi00829a059. PMID 4887858. 

[edit] External links

The CAS registry number for this enzyme class is 37289-08-0.

• IUBMB entry for 3.5.1.27

• KEGG entry for 3.5.1.27

• BRENDA entry for 3.5.1.27

• NiceZyme view of 3.5.1.27

• EC2PDB: PDB structures for 3.5.1.27

• PRIAM entry for 3.5.1.27

• PUMA2 entry for 3.5.1.27

• IntEnz: Integrated Enzyme entry for 3.5.1.27

• MetaCyc entry for 3.5.1.27

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047410: N-formylmethionylaminoacyl-tRNA deformylase

• AMIGO entry for GO code 0047410: N-formylmethionylaminoacyl-tRNA deformylase