N-arachidonoyl-dopamine

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N-arachidonoyl-dopamine
IUPAC name (5Z,8Z,11Z,14Z)-N-[2-(3,4-dihydroxyphenyl)

ethyl]icosa-5,8,11,14-tetraenamide
Other names NADA
Identifiers
CAS number [199875-69-9]
PubChem 5282105
SMILES CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(=O)

NCCC1=CC(=C(C=C1)O)O
Properties
Molecular formula C28H41NO3
Molar mass 439.63 g/mol
Except where noted otherwise, data are given for
materials in their standard state
(at 25 °C, 100 kPa)
Infobox disclaimer and references

N-arachidonoyl-dopamine, or NADA is a ligand (or chemical 'key') agonist (activator) to CB1 receptors which is an activation site for endocannabinoid and endovanilloid (aka vanilloid) ligands[1]. Specifically, NADA binds to both TRPV1 (a TRP-vanilloid cation channel receptor) and CB1 (an endocannabinoid receptor), a peculiarity among neurochemicals which normally bind to only one type of receptor.

[edit] References

  1. ^ Ralevic V. (July 2003). "Cannabinoid modulation of peripheral autonomic and sensory neurotransmission.". European journal of pharmacology 472 (1-2): 1–21. doi:10.1016/S0014-2999(03)01813-2. PMID 12860468. 

[edit] External links









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