N-acylsphingosine galactosyltransferase

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In enzymology, a N-acylsphingosine galactosyltransferase (EC 2.4.1.47) is an enzyme that catalyzes the chemical reaction

UDP-galactose + N-acylsphingosine UDP + D-galactosylceramide

Thus, the two substrates of this enzyme are UDP-galactose and N-acylsphingosine, whereas its two products are UDP and D-galactosylceramide.

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-galactose:N-acylsphingosine D-galactosyltransferase. Other names in common use include UDP galactose-N-acylsphingosine galactosyltransferase, and uridine diphosphogalactose-acylsphingosine galactosyltransferase. This enzyme participates in sphingolipid metabolism.

[edit] References

• IUBMB entry for 2.4.1.47
• BRENDA references for 2.4.1.47 (Recommended.)
• PubMed references for 2.4.1.47
• PubMed Central references for 2.4.1.47
• Google Scholar references for 2.4.1.47
• Fujino Y, Nakano M (1969). "Enzymic synthesis of cerebroside from ceramide and uridine diphosphate galactose". Biochem. J. 113: 573–5. PMID 5807218. 

[edit] External links

The CAS registry number for this enzyme class is 37277-56-8.

• IUBMB entry for 2.4.1.47

• KEGG entry for 2.4.1.47

• BRENDA entry for 2.4.1.47

• NiceZyme view of 2.4.1.47

• EC2PDB: PDB structures for 2.4.1.47

• PRIAM entry for 2.4.1.47

• PUMA2 entry for 2.4.1.47

• IntEnz: Integrated Enzyme entry for 2.4.1.47

• MetaCyc entry for 2.4.1.47

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047263: N-acylsphingosine galactosyltransferase

• AMIGO entry for GO code 0047263: N-acylsphingosine galactosyltransferase