N-acylglucosamine 2-epimerase

From Wikipedia, the free encyclopedia

In enzymology, a N-acylglucosamine 2-epimerase (EC 5.1.3.8) is an enzyme that catalyzes the chemical reaction

N-acyl-D-glucosamine N-acyl-D-mannosamine

Hence, this enzyme has one substrate, N-acyl-D-glucosamine, and one product, N-acyl-D-mannosamine.

This enzyme belongs to the family of isomerases, specifically those racemases and epimerases acting on carbohydrates and derivatives. The systematic name of this enzyme class is N-acyl-D-glucosamine 2-epimerase. Other names in common use include acylglucosamine 2-epimerase, and N-acetylglucosamine 2-epimerase. This enzyme participates in aminosugars metabolism. It employs one cofactor, ATP.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1FP3.

[edit] References

• IUBMB entry for 5.1.3.8
• BRENDA references for 5.1.3.8 (Recommended.)
• PubMed references for 5.1.3.8
• PubMed Central references for 5.1.3.8
• Google Scholar references for 5.1.3.8
• Ghosh S and Roseman S (1965). "The sialic acids. V. N-Acyl-D-glucosamine 2-epimerase". J. Biol. Chem. 240: 1531–1536. 

[edit] External links

The CAS registry number for this enzyme class is 37318-34-6.

• IUBMB entry for 5.1.3.8

• KEGG entry for 5.1.3.8

• BRENDA entry for 5.1.3.8

• NiceZyme view of 5.1.3.8

• EC2PDB: PDB structures for 5.1.3.8

• PRIAM entry for 5.1.3.8

• PUMA2 entry for 5.1.3.8

• IntEnz: Integrated Enzyme entry for 5.1.3.8

• MetaCyc entry for 5.1.3.8

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050121: N-acylglucosamine 2-epimerase

• AMIGO entry for GO code 0050121: N-acylglucosamine 2-epimerase