N-acetyltransferase 2

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N-acetyltransferase 2 (arylamine N-acetyltransferase)
PDB rendering based on 2pfr.
Available structures: 2pfr
Identifiers
Symbol(s) NAT2; AAC2
External IDs OMIM: 243400 MGI: 97279 HomoloGene: 32047
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 10 17960
Ensembl ENSG00000156006 ENSMUSG00000025588
Uniprot P11245 Q546L3
Refseq NM_000015 (mRNA)
NP_000006 (protein)		 NM_008673 (mRNA)
NP_032699 (protein)
Location Chr 8: 18.29 - 18.3 Mb Chr 8: 70.42 - 70.42 Mb
Pubmed search [1] [2]

N-acetyltransferase 2 (arylamine N-acetyltransferase), also known as NAT2, is a human gene.

This gene encodes N-acetyltransferase 2 (arylamine N-acetyltransferase 2). This enzyme functions to both activate and deactivate arylamine and hydrazine drugs and carcinogens. Polymorphisms in this gene are reponsible for the N-acetylation polymorphism in which human populations segregate into rapid,intermediate, and slow acetylator phenotypes. Polymorphisms in NAT2 are also associated with higher incidences of cancer and drug toxicity. A second arylamine N-acetyltransferase gene (NAT1) is located near NAT2.[1]

[edit] References

  1. ^ Entrez Gene: NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase).

[edit] Further reading

  • Vatsis KP, Weber WW, Bell DA, et al. (1995). "Nomenclature for N-acetyltransferases.". Pharmacogenetics 5 (1): 1–17. PMID 7773298. 
  • Windmill KF, McKinnon RA, Zhu X, et al. (1997). "The role of xenobiotic metabolizing enzymes in arylamine toxicity and carcinogenesis: functional and localization studies.". Mutat. Res. 376 (1-2): 153–60. PMID 9202751. 
  • Lan Q, Rothman N, Chow WH, et al. (2003). "No apparent association between NAT1 and NAT2 genotypes and risk of stomach cancer.". Cancer Epidemiol. Biomarkers Prev. 12 (4): 384–6. PMID 12692115. 
  • Ochs-Balcom HM, Wiesner G, Elston RC (2007). "A meta-analysis of the association of N-acetyltransferase 2 gene (NAT2) variants with breast cancer.". Am. J. Epidemiol. 166 (3): 246–54. doi:10.1093/aje/kwm066. PMID 17535831. 
  • Sanderson S, Salanti G, Higgins J (2007). "Joint effects of the N-acetyltransferase 1 and 2 (NAT1 and NAT2) genes and smoking on bladder carcinogenesis: a literature-based systematic HuGE review and evidence synthesis.". Am. J. Epidemiol. 166 (7): 741–51. doi:10.1093/aje/kwm167. PMID 17675654. 
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