N-acetylglucosamine kinase

From Wikipedia, the free encyclopedia

In enzymology, a N-acetylglucosamine kinase (EC 2.7.1.59) is an enzyme that catalyzes the chemical reaction

ATP + N-acetyl-D-glucosamine $\rightleftharpoons$ ADP + N-acetyl-D-glucosamine 6-phosphate

Thus, the two substrates of this enzyme are ATP and N-acetyl-D-glucosamine, whereas its two products are ADP and N-acetyl-D-glucosamine 6-phosphate.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:N-acetyl-D-glucosamine 6-phosphotransferase. Other names in common use include acetylglucosamine kinase (phosphorylating), ATP:2-acetylamino-2-deoxy-D-glucose 6-phosphotransferase, 2-acetylamino-2-deoxy-D-glucose kinase, and acetylaminodeoxyglucokinase. This enzyme participates in glutamate metabolism and aminosugars metabolism.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 2CH5, 2CH6, and 2HOE.

[edit] References

IUBMB entry for 2.7.1.59
BRENDA references for 2.7.1.59 (Recommended.)
PubMed references for 2.7.1.59
PubMed Central references for 2.7.1.59
Google Scholar references for 2.7.1.59
Asensio C and Ruiz-Amil M (1966). "N-Acetyl-D-glucosamine kinase. II. Escherichia coli". Methods Enzymol. 9: 421–425.
Barkulis SS (1966). "N-Acetyl-D-glucosamine kinase. I. Streptococcus pyrogenes". Methods Enzymol. 9: 415–420.
Datta A (1970). "Studies on hog spleen N-acetylglucosamine kinase. I. Purification and properties of N-acetylglucosamine kinase". Biochim. Biophys. Acta. 220: 51–60. PMID 4319609.