N-acetylglucosamine-6-phosphate deacetylase

From Wikipedia, the free encyclopedia

In enzymology, a N-acetylglucosamine-6-phosphate deacetylase (EC 3.5.1.25) is an enzyme that catalyzes the chemical reaction

N-acetyl-D-glucosamine 6-phosphate + H₂O D-glucosamine 6-phosphate + acetate

Thus, the two substrates of this enzyme are N-acetyl-D-glucosamine 6-phosphate and H₂O, whereas its two products are D-glucosamine 6-phosphate and acetate.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is N-acetyl-D-glucosamine-6-phosphate amidohydrolase. Other names in common use include acetylglucosamine phosphate deacetylase, acetylaminodeoxyglucosephosphate acetylhydrolase, and 2-acetamido-2-deoxy-D-glucose-6-phosphate amidohydrolase. This enzyme participates in aminosugars metabolism.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes 1O12, 1UN7, 1YMY, 1YRR, 2P50, and 2P53.

[edit] References

• IUBMB entry for 3.5.1.25
• BRENDA references for 3.5.1.25 (Recommended.)
• PubMed references for 3.5.1.25
• PubMed Central references for 3.5.1.25
• Google Scholar references for 3.5.1.25
• White RJ, Pasternak CA (1967). "The purification and properties of N-acetylglucosamine 6-phosphate deacetylase from Escherichia coli". Biochem. J. 105: 121–5. PMID 4861885. 
• Yamano N, Matsushita Y, Kamada Y, Fujishima S, Arita M (1996). "Purification and characterization of N-acetylglucosamine 6-phosphate deacetylase with activity against N-acetylglucosamine from Vibrio cholerae non-O1". Biosci. Biotechnol. Biochem. 60: 1320–3. PMID 8987551. 

[edit] External links

The CAS registry number for this enzyme class is 9027-50-3.

• IUBMB entry for 3.5.1.25

• KEGG entry for 3.5.1.25

• BRENDA entry for 3.5.1.25

• NiceZyme view of 3.5.1.25

• EC2PDB: PDB structures for 3.5.1.25

• PRIAM entry for 3.5.1.25

• PUMA2 entry for 3.5.1.25

• IntEnz: Integrated Enzyme entry for 3.5.1.25

• MetaCyc entry for 3.5.1.25

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0008448: N-acetylglucosamine-6-phosphate deacetylase

• AMIGO entry for GO code 0008448: N-acetylglucosamine-6-phosphate deacetylase