N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase

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In enzymology, a N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase (EC 3.1.4.45) is an enzyme that catalyzes the chemical reaction

glycoprotein N-acetyl-D-glucosaminyl-phospho-D-mannose + H₂O $\rightleftharpoons$ N-acetyl-D-glucosamine + glycoprotein phospho-D-mannose

Thus, the two substrates of this enzyme are glycoprotein N-acetyl-D-glucosaminyl-phospho-D-mannose and H₂O, whereas its two products are N-acetyl-D-glucosamine and glycoprotein phospho-D-mannose.

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric diester bonds. The systematic name of this enzyme class is glycoprotein-N-acetyl-D-glucosaminyl-phospho-D-mannose N-acetyl-D-glucosaminylphosphohydrolase. Other names in common use include alpha-N-acetylglucosaminyl phosphodiesterase, lysosomal alpha-N-acetylglucosaminidase, phosphodiester glycosidase, alpha-N-acetyl-D-glucosamine-1-phosphodiester, N-acetylglucosaminidase, 2-acetamido-2-deoxy-alpha-D-glucose 1-phosphodiester, and acetamidodeoxyglucohydrolase.

[edit] References

IUBMB entry for 3.1.4.45
BRENDA references for 3.1.4.45 (Recommended.)
PubMed references for 3.1.4.45
PubMed Central references for 3.1.4.45
Google Scholar references for 3.1.4.45
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